| pubmed-article:12196564 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12196564 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:12196564 | lifeskim:mentions | umls-concept:C2325162 | lld:lifeskim |
| pubmed-article:12196564 | lifeskim:mentions | umls-concept:C0037492 | lld:lifeskim |
| pubmed-article:12196564 | lifeskim:mentions | umls-concept:C1419854 | lld:lifeskim |
| pubmed-article:12196564 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:12196564 | pubmed:dateCreated | 2002-8-27 | lld:pubmed |
| pubmed-article:12196564 | pubmed:abstractText | This is the first examination of sensory receptive properties and associated electrophysiological properties in vivo of dorsal root ganglion (DRG) neurons that express the TTX-resistant sodium channel Na(v)1.9 (NaN). Intracellular recordings in lumbar DRGs in Wistar rats enabled units with dorsal root C-, Adelta-, or Aalpha/beta-fibers to be classified as nociceptive, low-threshold mechanoreceptive (LTM), or unresponsive. Intracellular dye injection enabled subsequent immunocytochemistry for Na(v)1.9-like immunoreactivity (Na(v)1.9-LI). Na(v)1.9-LI was expressed selectively in nociceptive-type (C- and A-fiber nociceptive and C-unresponsive) units. Of the nociceptive units, 64, 54, and 31% of C-, Adelta-, and Aalpha/beta-fiber units, respectively, were positive for Na(v)1.9-LI. C-unresponsive units were included in the nociceptive-type group on the basis of their nociceptor-like membrane properties; 91% were positive. Na(v)1.9-LI was undetectable in Adelta- or Aalpha/beta-fiber LTM units and in one C-LTM unit. Na(v)1.9-LI intensity was correlated negatively with soma size and conduction velocity in nociceptive units and with conduction velocity in C-fiber units. There was a positive correlation with action potential rise time in nociceptive-type units with membrane potentials equal to or more negative than -50 mV. The data provide direct evidence that Na(v)1.9 is expressed selectively in (but not in all) C- and A-fiber nociceptive-type units and suggest that Na(v)1.9 contributes to membrane properties that are typical of nociceptive neurons. | lld:pubmed |
| pubmed-article:12196564 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12196564 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12196564 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12196564 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12196564 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:12196564 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:12196564 | pubmed:author | pubmed-author:WaxmanStephen... | lld:pubmed |
| pubmed-article:12196564 | pubmed:author | pubmed-author:BlackJoel AJA | lld:pubmed |
| pubmed-article:12196564 | pubmed:author | pubmed-author:Dib-HajjSulay... | lld:pubmed |
| pubmed-article:12196564 | pubmed:author | pubmed-author:FangXinX | lld:pubmed |
| pubmed-article:12196564 | pubmed:author | pubmed-author:DjouhriLaiche... | lld:pubmed |
| pubmed-article:12196564 | pubmed:author | pubmed-author:LawsonSally... | lld:pubmed |
| pubmed-article:12196564 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12196564 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:12196564 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12196564 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12196564 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12196564 | pubmed:pagination | 7425-33 | lld:pubmed |
| pubmed-article:12196564 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:12196564 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12196564 | pubmed:articleTitle | The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons. | lld:pubmed |
| pubmed-article:12196564 | pubmed:affiliation | Department of Physiology, University of Bristol, Medical School, Bristol BS8 1TD, United Kingdom. | lld:pubmed |
| pubmed-article:12196564 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12196564 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:12196564 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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