The RING finger proteins function in a variety of fundamental cellular processes. The products of some members of the Polycomb group (PcG) bear ring finger domains and are defined as a subclass of RING finger proteins. Among them are Drosophila posterior sex combs and suppressor 2 of zeste, whose RING fingers are conserved in vertebrate PcG proteins Mel18 and Bmi1.
Department of Cellular, Molecular and Developmental Biology, University of Michigan, 830 N University, Ann Arbor, MI 48109-1048, USA. takasaka@umich.edu
