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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0021666,
umls-concept:C0024742,
umls-concept:C0035647,
umls-concept:C0185117,
umls-concept:C0205281,
umls-concept:C0443199,
umls-concept:C0597357,
umls-concept:C1512505,
umls-concept:C2911684
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pubmed:issue |
8
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pubmed:dateCreated |
2002-8-7
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pubmed:abstractText |
Hypersecretion of the precursor of the lysosomal protease cathepsin D (procathepsin D) has been implicated in the invasive phenotype of human breast cancer. However, the mechanism of the abnormal secretion of procathepsin D remains unclear. Since the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) plays a central role in the intracellular transport and endocytosis of M6P-containing lysosomal enzymes, a deficiency in functional M6P/IGF2R may underlie the hypersecretion of procathepsin D in invasive tumors.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1234-1010
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
BR293-300
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12165733-3' Untranslated Regions,
pubmed-meshheading:12165733-Breast Neoplasms,
pubmed-meshheading:12165733-Cathepsin D,
pubmed-meshheading:12165733-Enzyme Precursors,
pubmed-meshheading:12165733-Female,
pubmed-meshheading:12165733-Humans,
pubmed-meshheading:12165733-Mutation,
pubmed-meshheading:12165733-RNA, Messenger,
pubmed-meshheading:12165733-Receptor, IGF Type 2,
pubmed-meshheading:12165733-Sequence Analysis, DNA,
pubmed-meshheading:12165733-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Differential expression of the mannose 6-phosphate/ insulin-like growth factor-II receptor in human breast cancer cell lines of different invasive potential.
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pubmed:affiliation |
Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. kang.jing@mgh.harvard.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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