| pubmed-article:12165097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C0224522 | lld:lifeskim |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C1418776 | lld:lifeskim |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:12165097 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:12165097 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:12165097 | pubmed:dateCreated | 2002-8-7 | lld:pubmed |
| pubmed-article:12165097 | pubmed:abstractText | Peroxisome proliferator-activated receptor gamma (PPARgamma) is a ligand dependent transcriptional factor known to be a regulator of adipogenesis. Recent studies have also shown that stimulation of PPARgamma inhibits the transcriptional activities of other nuclear factors and down-regulates proinflammatory cytokine synthesis in T cells and monocytes. We examined, in the present study, the functional significance of PPARgamma expressed in fibroblast-like synovial cells (FLS) isolated from patients with rheumatoid arthritis (RA). Incubation of FLS with a synthetic PPARgamma ligand, troglitazone, inhibited endogenous production of TNF-alpha, IL-6 and IL-8, as well as matrix metalloprotease-3 (MMP-3), without inducing apoptosis of the cells. The gelatinase activity of FLS culture media was also inhibited by troglitazone. Electrophoretic mobility shift assay (EMSA) showed a significant reduction in the DNA binding activity of NF-kappaB in troglitazone-treated FLS in response to TNF-alpha or IL-1beta. Moreover, long-term cultivation of FLS with troglitazone resulted in morphological changes with marked lipid accumulation in these cells. Our results show a negative regulatory function for PPARgamma on cytokine and MMP production together with inhibition of cytokine-mediated inflammatory responses in rheumatoid synovial cells. Our results also suggest that FLS could differentiate into adipocyte-like cells in the presence of proper stimulatory signals including PPARgamma. | lld:pubmed |
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| pubmed-article:12165097 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12165097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12165097 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12165097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12165097 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:12165097 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:12165097 | pubmed:author | pubmed-author:IdaHH | lld:pubmed |
| pubmed-article:12165097 | pubmed:author | pubmed-author:MiyashitaTT | lld:pubmed |
| pubmed-article:12165097 | pubmed:author | pubmed-author:NakashimaTT | lld:pubmed |
| pubmed-article:12165097 | pubmed:author | pubmed-author:YamasakiSS | lld:pubmed |
| pubmed-article:12165097 | pubmed:author | pubmed-author:NakataKK | lld:pubmed |
| pubmed-article:12165097 | pubmed:author | pubmed-author:EguchiKK | lld:pubmed |
| pubmed-article:12165097 | pubmed:author | pubmed-author:KawakamiAA | lld:pubmed |
| pubmed-article:12165097 | pubmed:author | pubmed-author:MigitaKK | lld:pubmed |
| pubmed-article:12165097 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12165097 | pubmed:volume | 129 | lld:pubmed |
| pubmed-article:12165097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12165097 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12165097 | pubmed:pagination | 379-84 | lld:pubmed |
| pubmed-article:12165097 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12165097 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12165097 | pubmed:articleTitle | Functional changes in rheumatoid fibroblast-like synovial cells through activation of peroxisome proliferator-activated receptor gamma-mediated signalling pathway. | lld:pubmed |
| pubmed-article:12165097 | pubmed:affiliation | First Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. | lld:pubmed |
| pubmed-article:12165097 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12165097 | pubmed:publicationType | In Vitro | lld:pubmed |
