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rdf:type |
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lifeskim:mentions |
umls-concept:C0025519,
umls-concept:C0028778,
umls-concept:C0080194,
umls-concept:C0162714,
umls-concept:C0184511,
umls-concept:C0205145,
umls-concept:C0205464,
umls-concept:C0243071,
umls-concept:C0332206,
umls-concept:C0376637,
umls-concept:C0521026,
umls-concept:C1656349,
umls-concept:C1979963,
umls-concept:C2003903
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pubmed:issue |
17
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pubmed:dateCreated |
2002-8-5
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pubmed:abstractText |
Indinavir analogues with blocked metabolism sites show highly improved pharmacokinetic profiles in animals. The cis-aminochromanol substituted analogues exhibited excellent potency against both the wild-type (NL4-3) virus and protease inhibitor-resistant HIV strains.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:ChapmanKevin TKT,
pubmed-author:ChengYuanY,
pubmed-author:EminiEmilio AEA,
pubmed-author:GabryelskiLoriL,
pubmed-author:JinLixiaL,
pubmed-author:LinJiunn HJH,
pubmed-author:LuZhijianZ,
pubmed-author:OlsenDavid BDB,
pubmed-author:RanoThomas ATA,
pubmed-author:RutkowskiCarrie ACA,
pubmed-author:SchleifWilliam AWA,
pubmed-author:StahlhutMarkM,
pubmed-author:TataJames RJR,
pubmed-author:ZhangFengqiF
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pubmed:issnType |
Print
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pubmed:day |
2
|
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pubmed:volume |
12
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2419-22
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12161147-Animals,
pubmed-meshheading:12161147-Area Under Curve,
pubmed-meshheading:12161147-Dogs,
pubmed-meshheading:12161147-Drug Resistance,
pubmed-meshheading:12161147-HIV,
pubmed-meshheading:12161147-HIV Protease,
pubmed-meshheading:12161147-HIV Protease Inhibitors,
pubmed-meshheading:12161147-Humans,
pubmed-meshheading:12161147-Indinavir,
pubmed-meshheading:12161147-Inhibitory Concentration 50,
pubmed-meshheading:12161147-Metabolic Clearance Rate,
pubmed-meshheading:12161147-Structure-Activity Relationship,
pubmed-meshheading:12161147-Tumor Cells, Cultured
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pubmed:year |
2002
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pubmed:articleTitle |
Indinavir analogues with blocked metabolism sites as HIV protease inhibitors with improved pharmacological profiles and high potency against PI-resistant viral strains.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. yuan_cheng@merck.com
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pubmed:publicationType |
Journal Article
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