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pubmed-article:12127506pubmed:abstractTextSynthetic intermediates of alkaloid halichlorine with the azaspiro core structure have been found to induce apoptosis of cultured human cells including an acute monocytic leukemia cell line (THP-1) at micromolar concentrations. The novel biological activity of the intermediates was suggested to depend on the skeletal structure and silyloxymethyl functionality on the five-membered ring.lld:pubmed
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pubmed-article:12127506pubmed:articleTitleApoptosis-inducing activity of synthetic intermediates of halichlorine.lld:pubmed
pubmed-article:12127506pubmed:affiliationInstitute for Medicinal Resources, University of Tokushima, Sho-machi 1-78, 770-8505, Tokushima, Japan.lld:pubmed
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