Source:http://linkedlifedata.com/resource/pubmed/id/12126946
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2002-7-19
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pubmed:abstractText |
Autosomal dominant spinocerebellar ataxia 7 is associated with retinal degeneration. SCA7, the causative gene, encodes ataxin-7, a ubiquitous 892 amino acid protein of variable sub-cellular localization, and the disease is due to expansion of an unstable CAG repeat in the coding region of the gene. Recent increases in understanding of the mechanisms ofSCA7 -related retinopathy from in vitro and murine model studies prompted us to perform a detailed study of the retinal phenotype of affected members of a family with SCA7 mutation (45-47 CAG repeats). There was a spectrum of severity from mild to severe dysfunction. Early functional abnormalities were at both photoreceptor and post-receptoral levels. When cone and rod photoreceptor dysfunction was present, it was approximately equal. Regional retinal dysfunction was evident: there was more dysfunction centrally than peripherally with least effect in the midperiphery. In vivo cross-sectional retinal images with optical coherence tomography showed an early disease stage of altered foveal lamination (abnormal area of low reflectivity splitting the outer retina-choroidal complex) accompanied in the parafovea by reduced retinal thickness. Later disease stages showed foveal and parafoveal retinal thinning. The phenotype in this family with SCA7 is that of a cone-rod dystrophy. These observations increase interest in a recent hypothesis that ataxin-7 may interfere with the function of CRX (cone-rod homeobox), a transcription factor regulating photoreceptor genes and a cause of a cone-rod dystrophy phenotype in man.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-4835
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
737-45
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12126946-Adult,
pubmed-meshheading:12126946-Aged,
pubmed-meshheading:12126946-Electroretinography,
pubmed-meshheading:12126946-Female,
pubmed-meshheading:12126946-Humans,
pubmed-meshheading:12126946-Male,
pubmed-meshheading:12126946-Middle Aged,
pubmed-meshheading:12126946-Mutation,
pubmed-meshheading:12126946-Nerve Tissue Proteins,
pubmed-meshheading:12126946-Pedigree,
pubmed-meshheading:12126946-Phenotype,
pubmed-meshheading:12126946-Retinal Cone Photoreceptor Cells,
pubmed-meshheading:12126946-Retinal Degeneration,
pubmed-meshheading:12126946-Retinal Rod Photoreceptor Cells,
pubmed-meshheading:12126946-Spinocerebellar Ataxias,
pubmed-meshheading:12126946-Visual Field Tests,
pubmed-meshheading:12126946-Visual Fields
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pubmed:year |
2002
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pubmed:articleTitle |
Spinocerebellar ataxia type 7 (SCA7) shows a cone-rod dystrophy phenotype.
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pubmed:affiliation |
Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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