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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-7-16
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pubmed:abstractText |
Interleukin 10 (IL-10) is an immunosuppressive cytokine produced by T-lymphocytes, and is a regulatory molecule for angiogenesis in various cancers. We examined IL-10 and vascular endothelial growth factor (VEGF) gene expression in 45 esophageal cancer patients who underwent surgical resection. Thirty-seven (82.2%) of the 45 esophageal cancers revealed IL-10 gene expression. VEGF121, VEGF165 and VEGF189 isoforms were detected in 93.3% (42/45), 55.6% (25/45) and 26.7% (12/45) of cases, respectively. IL-10 gene expression was significantly correlated with VEGF121 gene expression (P=0.0039, Fisher's test). The results suggested that IL-10 stimulates angiogenic factor gene expression.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inducing Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1107-3756
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
169-72
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pubmed:dateRevised |
2007-5-2
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pubmed:meshHeading |
pubmed-meshheading:12119553-Alternative Splicing,
pubmed-meshheading:12119553-Angiogenesis Inducing Agents,
pubmed-meshheading:12119553-Carcinoma, Squamous Cell,
pubmed-meshheading:12119553-Esophageal Neoplasms,
pubmed-meshheading:12119553-Female,
pubmed-meshheading:12119553-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12119553-Humans,
pubmed-meshheading:12119553-Interleukin-10,
pubmed-meshheading:12119553-Male,
pubmed-meshheading:12119553-Neoplasm Proteins,
pubmed-meshheading:12119553-Neovascularization, Pathologic,
pubmed-meshheading:12119553-Protein Isoforms,
pubmed-meshheading:12119553-RNA, Messenger,
pubmed-meshheading:12119553-RNA, Neoplasm,
pubmed-meshheading:12119553-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12119553-Vascular Endothelial Growth Factor A
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pubmed:year |
2002
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pubmed:articleTitle |
Correlation between interleukin 10 and vascular endothelial growth factor expression in human esophageal cancer.
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pubmed:affiliation |
Department of Pathology, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa 259-1193, Japan.
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pubmed:publicationType |
Journal Article
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