| pubmed-article:12065415 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12065415 | lifeskim:mentions | umls-concept:C0084178 | lld:lifeskim |
| pubmed-article:12065415 | lifeskim:mentions | umls-concept:C1706022 | lld:lifeskim |
| pubmed-article:12065415 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:12065415 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:12065415 | lifeskim:mentions | umls-concept:C0248587 | lld:lifeskim |
| pubmed-article:12065415 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12065415 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:12065415 | pubmed:dateCreated | 2002-6-14 | lld:pubmed |
| pubmed-article:12065415 | pubmed:abstractText | E2F transcription factors play a major role in controlling mammalian cell cycle progression. We recently reported that a potential tumor suppressor, prohibitin, which interacts with retinoblastoma protein (Rb), regulates E2F function and this activity correlates with its growth-suppressive activity. We show here that prohibitin recruits Brg-1/Brm to E2F-responsive promoters, and that this recruitment is required for the repression of E2F-mediated transcription by prohibitin. Expression of a dominant-negative Brg-1 or Brm releases prohibitin-mediated repression of E2F and relieves prohibitin-mediated growth suppression. Although prohibitin associates with, and recruits, Brg-1 and Brm independently of Rb, prohibitin/Brg-1/Brm-mediated transcriptional repression requires Rb. A viral oncoprotein, SV40 large T antigen, can reverse prohibitin-mediated suppression of E2F-mediated gene transcription, and targets prohibitin through interruption of the association between prohibitin and Brg-1/Brm without affecting the prohibitin-E2F interaction. | lld:pubmed |
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| pubmed-article:12065415 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:12065415 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12065415 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12065415 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:12065415 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:12065415 | pubmed:author | pubmed-author:FallerDouglas... | lld:pubmed |
| pubmed-article:12065415 | pubmed:author | pubmed-author:WangShengS | lld:pubmed |
| pubmed-article:12065415 | pubmed:author | pubmed-author:ZhangBaohuaB | lld:pubmed |
| pubmed-article:12065415 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12065415 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:12065415 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:12065415 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12065415 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12065415 | pubmed:pagination | 3019-28 | lld:pubmed |
| pubmed-article:12065415 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:12065415 | pubmed:meshHeading | pubmed-meshheading:12065415... | lld:pubmed |
| pubmed-article:12065415 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12065415 | pubmed:articleTitle | Prohibitin requires Brg-1 and Brm for the repression of E2F and cell growth. | lld:pubmed |
| pubmed-article:12065415 | pubmed:affiliation | Boston University School of Medicine, Cancer Research Center, 715 Albany Street, Boston, MA 02118, USA. sw184@bu.edu | lld:pubmed |
| pubmed-article:12065415 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12065415 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
