Source:http://linkedlifedata.com/resource/pubmed/id/12063546
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2002-6-13
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| pubmed:abstractText |
Although Epstein-Barr virus (EBV) infection has been implicated in the development of a subset of Hodgkin's disease, the etiology of EBV-negative Hodgkin's disease remains to be determined. We investigated the status of human cytomegalovirus (hCMV) infection in 42 cases of Hodgkin's disease in a Chinese population. Using a nested polymerase chain reaction assay, nine of the 42 cases (21.4%) were found to contain EBV DNA. While only one of the nine EBV-positive cases demonstrated amplifiable hCMV DNA, approximately 33.3% of the EBV-negative cases (11/33) showed molecular evidence of hCMV infection (8 mixed cellularity; 2 nodular sclerosis; and 1 lymphocyte depletion). All 17 lymph nodes with non-specific reactive changes were negative for hCMV DNA. The presence of hCMV in Reed-Sternberg cells and their variants was further confirmed by single-cell polymerase chain reaction, in situ hybridization and immunohistochemical analysis, which demonstrated ~50% amplified hCMV DNA. These results suggest for the first time that hCMV infection plays a potential role in signaling the cell transformation and pathogenesis of Hodgkin's disease, particularly in EBV-negative cases.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
1019-6439
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
21
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
31-6
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12063546-Adolescent,
pubmed-meshheading:12063546-Adult,
pubmed-meshheading:12063546-Child,
pubmed-meshheading:12063546-Child, Preschool,
pubmed-meshheading:12063546-Cytomegalovirus,
pubmed-meshheading:12063546-Cytomegalovirus Infections,
pubmed-meshheading:12063546-DNA, Viral,
pubmed-meshheading:12063546-Female,
pubmed-meshheading:12063546-Herpesviridae Infections,
pubmed-meshheading:12063546-Herpesvirus 4, Human,
pubmed-meshheading:12063546-Hodgkin Disease,
pubmed-meshheading:12063546-Humans,
pubmed-meshheading:12063546-Immunoenzyme Techniques,
pubmed-meshheading:12063546-Lymph Nodes,
pubmed-meshheading:12063546-Male,
pubmed-meshheading:12063546-Middle Aged,
pubmed-meshheading:12063546-Nucleic Acid Hybridization,
pubmed-meshheading:12063546-Polymerase Chain Reaction,
pubmed-meshheading:12063546-Reed-Sternberg Cells
|
| pubmed:year |
2002
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| pubmed:articleTitle |
Human cytomegalovirus in neoplastic cells of Epstein-Barr virus negative Hodgkin's disease.
|
| pubmed:affiliation |
Department of Pathology, XiJin Hospital, The Fourth Military Medical University, Xi'an 710032, PR China. huanggs@fmmu.edu.cn
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|