Linked Life Data

12048257

Source:http://linkedlifedata.com/resource/pubmed/id/12048257

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12048257rdf:typepubmed:Citationlld:pubmed
pubmed-article:12048257lifeskim:mentionsumls-concept:C0227651lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C0011881lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C0288472lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C0020374lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C0174045lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C0249197lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C1420626lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C0086982lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C1709059lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C0243077lld:lifeskim
pubmed-article:12048257lifeskim:mentionsumls-concept:C1514485lld:lifeskim
pubmed-article:12048257pubmed:issue12lld:pubmed
pubmed-article:12048257pubmed:dateCreated2002-6-12lld:pubmed
pubmed-article:12048257pubmed:abstractTextInhibitors of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, also known as statins, are lipid-lowering agents widely used in the prevention of coronary heart disease. Recent experimental and clinical data, however, indicate that the overall benefits of statin therapy may exceed its cholesterol-lowering properties. We postulate that statins may ameliorate the detrimental effects of high glucose (HG)-induced proliferation of mesangial cells (MCs), a feature of early stages of diabetic nephropathy, by preventing Rho isoprenylation. Rat MCs cultured in HG milieu were treated with and without simvastatin, an HMG-CoA reductase inhibitor. Simvastatin inhibited HG-induced MC proliferation as measured by [(3)H]thymidine incorporation. This inhibitory effect was reversed with geranylgeranyl pyrophosphate, an isoprenoid intermediate of the cholesterol biosynthetic pathway. At the cell-cycle level, the HG-induced proliferation of MCs was associated with a decrease in cyclin dependent kinase (CDK) inhibitor p21 protein expression accompanied by an increase in CDK4 and CDK2 kinase activities. Simvastatin reversed the down-regulation of p21 protein expression and decreased CDK4 and CDK2 kinase activities. Exposure of MCs to HG was associated with an increase in membrane-associated Ras and Rho GTPase protein expression. Cotreatment of MCs with simvastatin reversed HG-induced Ras and Rho membrane translocation. Immunofluorescence microscopy revealed that the overexpression of the dominant-negative RhoA led to a significant increase in p21 expression. Our data suggest that simvastatin represses the HG-induced Rho GTPase/p21 signaling in glomerular MCs. Thus, this study provides a molecular basis for the use of statins, independently of their cholesterol-lowering effect, in early stages of diabetic nephropathy.lld:pubmed
pubmed-article:12048257pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:languageenglld:pubmed
pubmed-article:12048257pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:citationSubsetIMlld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12048257pubmed:statusMEDLINElld:pubmed
pubmed-article:12048257pubmed:monthJunlld:pubmed
pubmed-article:12048257pubmed:issn0027-8424lld:pubmed
pubmed-article:12048257pubmed:authorpubmed-author:SunLinLlld:pubmed
pubmed-article:12048257pubmed:authorpubmed-author:KanwarYashpal...lld:pubmed
pubmed-article:12048257pubmed:authorpubmed-author:DaneshFarhad...lld:pubmed
pubmed-article:12048257pubmed:authorpubmed-author:SadeghiMehran...lld:pubmed
pubmed-article:12048257pubmed:authorpubmed-author:AmroNailNlld:pubmed
pubmed-article:12048257pubmed:authorpubmed-author:PhilipsCarrie...lld:pubmed
pubmed-article:12048257pubmed:authorpubmed-author:ZengLixiaLlld:pubmed
pubmed-article:12048257pubmed:authorpubmed-author:SahaiAtulAlld:pubmed
pubmed-article:12048257pubmed:issnTypePrintlld:pubmed
pubmed-article:12048257pubmed:day11lld:pubmed
pubmed-article:12048257pubmed:volume99lld:pubmed
pubmed-article:12048257pubmed:ownerNLMlld:pubmed
pubmed-article:12048257pubmed:authorsCompleteYlld:pubmed
pubmed-article:12048257pubmed:pagination8301-5lld:pubmed
pubmed-article:12048257pubmed:dateRevised2009-11-19lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
pubmed-article:12048257pubmed:meshHeadingpubmed-meshheading:12048257...lld:pubmed
More...