| pubmed-article:12034039 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12034039 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:12034039 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:12034039 | lifeskim:mentions | umls-concept:C0009015 | lld:lifeskim |
| pubmed-article:12034039 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12034039 | lifeskim:mentions | umls-concept:C0765701 | lld:lifeskim |
| pubmed-article:12034039 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:12034039 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12034039 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12034039 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:12034039 | pubmed:dateCreated | 2002-5-29 | lld:pubmed |
| pubmed-article:12034039 | pubmed:abstractText | Interleukin-18 binding protein (IL-18BP) is a constitutively expressed and secreted protein that lacks a transmembrane domain. IL-18BP binds specifically to mature IL-18 and inhibits its activity. To study the immunomodulating role of IL-18BP in models of autoimmune diseases in rats, we cloned and characterized rat IL-18BP. Rat IL-18BP has 193 amino acid residues and is highly homologous to human and mouse IL-18BP. Recombinant rat IL-18BP binds to rat IL-18, reacts with antibodies to human or mouse IL-18BP, and inhibits IL-18-dependent interferon-gamma (IFN-gamma) production in vitro. Thus, rat IL-18BP can be employed to antagonize the proinflammatory responses induced by endogenous IL-18 in rat models of autoimmune diseases. | lld:pubmed |
| pubmed-article:12034039 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12034039 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12034039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12034039 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12034039 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:12034039 | pubmed:issn | 1079-9907 | lld:pubmed |
| pubmed-article:12034039 | pubmed:author | pubmed-author:DinarelloChar... | lld:pubmed |
| pubmed-article:12034039 | pubmed:author | pubmed-author:AzamTaniaT | lld:pubmed |
| pubmed-article:12034039 | pubmed:author | pubmed-author:KimSoo-HyunSH | lld:pubmed |
| pubmed-article:12034039 | pubmed:author | pubmed-author:VenkateshNata... | lld:pubmed |
| pubmed-article:12034039 | pubmed:author | pubmed-author:SouroujonMiri... | lld:pubmed |
| pubmed-article:12034039 | pubmed:author | pubmed-author:FuchsSaraS | lld:pubmed |
| pubmed-article:12034039 | pubmed:author | pubmed-author:ImSin-HyeogSH | lld:pubmed |
| pubmed-article:12034039 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12034039 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:12034039 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12034039 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12034039 | pubmed:pagination | 321-8 | lld:pubmed |
| pubmed-article:12034039 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:12034039 | pubmed:meshHeading | pubmed-meshheading:12034039... | lld:pubmed |
| pubmed-article:12034039 | pubmed:meshHeading | pubmed-meshheading:12034039... | lld:pubmed |
| pubmed-article:12034039 | pubmed:meshHeading | pubmed-meshheading:12034039... | lld:pubmed |
| pubmed-article:12034039 | pubmed:meshHeading | pubmed-meshheading:12034039... | lld:pubmed |
| pubmed-article:12034039 | pubmed:meshHeading | pubmed-meshheading:12034039... | lld:pubmed |
| pubmed-article:12034039 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:12034039 | pubmed:articleTitle | Rat interleukin-18 binding protein: cloning, expression, and characterization. | lld:pubmed |
| pubmed-article:12034039 | pubmed:affiliation | Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel. | lld:pubmed |
| pubmed-article:12034039 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12034039 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:12034039 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:29197 | entrezgene:pubmed | pubmed-article:12034039 | lld:entrezgene |
| entrez-gene:84388 | entrezgene:pubmed | pubmed-article:12034039 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:12034039 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:12034039 | lld:pubmed |
