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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2002-5-29
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pubmed:abstractText |
Interleukin-18 binding protein (IL-18BP) is a constitutively expressed and secreted protein that lacks a transmembrane domain. IL-18BP binds specifically to mature IL-18 and inhibits its activity. To study the immunomodulating role of IL-18BP in models of autoimmune diseases in rats, we cloned and characterized rat IL-18BP. Rat IL-18BP has 193 amino acid residues and is highly homologous to human and mouse IL-18BP. Recombinant rat IL-18BP binds to rat IL-18, reacts with antibodies to human or mouse IL-18BP, and inhibits IL-18-dependent interferon-gamma (IFN-gamma) production in vitro. Thus, rat IL-18BP can be employed to antagonize the proinflammatory responses induced by endogenous IL-18 in rat models of autoimmune diseases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1079-9907
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
22
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
321-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12034039-Amino Acid Sequence,
pubmed-meshheading:12034039-Animals,
pubmed-meshheading:12034039-Base Sequence,
pubmed-meshheading:12034039-COS Cells,
pubmed-meshheading:12034039-Cloning, Molecular,
pubmed-meshheading:12034039-Dose-Response Relationship, Drug,
pubmed-meshheading:12034039-Escherichia coli,
pubmed-meshheading:12034039-Gene Expression,
pubmed-meshheading:12034039-Glycoproteins,
pubmed-meshheading:12034039-Humans,
pubmed-meshheading:12034039-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:12034039-Interferon-gamma,
pubmed-meshheading:12034039-Interleukin-12,
pubmed-meshheading:12034039-Interleukin-18,
pubmed-meshheading:12034039-Molecular Sequence Data,
pubmed-meshheading:12034039-Rats,
pubmed-meshheading:12034039-Rats, Inbred Lew,
pubmed-meshheading:12034039-Recombinant Proteins,
pubmed-meshheading:12034039-Sequence Homology, Amino Acid
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pubmed:year |
2002
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pubmed:articleTitle |
Rat interleukin-18 binding protein: cloning, expression, and characterization.
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pubmed:affiliation |
Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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