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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0086418,
umls-concept:C0220781,
umls-concept:C0225369,
umls-concept:C0253373,
umls-concept:C0331858,
umls-concept:C0521339,
umls-concept:C1171362,
umls-concept:C1515670,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C1883254
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pubmed:issue |
5
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pubmed:dateCreated |
2002-5-24
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pubmed:abstractText |
We investigated whether chondrocytes derived from osteoarthritic cartilage may lose their responsiveness to cartilage-derived morphogenetic protein-1, -2 (CDMP-1, -2) and osteogenic protein-1 (OP-1) compared with healthy cells, thus leading to an impaired maintenance of matrix integrity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aggrecans,
http://linkedlifedata.com/resource/pubmed/chemical/BMP7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Protein 7,
http://linkedlifedata.com/resource/pubmed/chemical/Bone Morphogenetic Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Differentiation Factor 5,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/cartilage-derived-morphogenetic...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1063-4584
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2002 OsteoArthritis Research Society International. Published by Elsevier Science Ltd. All rights reserved.
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
394-401
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12027540-Adult,
pubmed-meshheading:12027540-Aged,
pubmed-meshheading:12027540-Aged, 80 and over,
pubmed-meshheading:12027540-Aggrecans,
pubmed-meshheading:12027540-Blotting, Northern,
pubmed-meshheading:12027540-Bone Morphogenetic Protein 7,
pubmed-meshheading:12027540-Bone Morphogenetic Proteins,
pubmed-meshheading:12027540-Cartilage, Articular,
pubmed-meshheading:12027540-Cell Culture Techniques,
pubmed-meshheading:12027540-Chondrocytes,
pubmed-meshheading:12027540-Collagen Type II,
pubmed-meshheading:12027540-Extracellular Matrix,
pubmed-meshheading:12027540-Extracellular Matrix Proteins,
pubmed-meshheading:12027540-Gene Expression Regulation,
pubmed-meshheading:12027540-Growth Differentiation Factor 5,
pubmed-meshheading:12027540-Growth Substances,
pubmed-meshheading:12027540-Humans,
pubmed-meshheading:12027540-Lectins, C-Type,
pubmed-meshheading:12027540-Middle Aged,
pubmed-meshheading:12027540-Osteoarthritis,
pubmed-meshheading:12027540-Proteoglycans,
pubmed-meshheading:12027540-RNA, Messenger,
pubmed-meshheading:12027540-Transforming Growth Factor beta
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pubmed:year |
2002
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pubmed:articleTitle |
Cartilage-derived morphogenetic protein-1 and -2 are endogenously expressed in healthy and osteoarthritic human articular chondrocytes and stimulate matrix synthesis.
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pubmed:affiliation |
Department of Rheumatology, Internal Medicine III, University of Vienna, Austria.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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