Linked Life Data

12016099

Source:http://linkedlifedata.com/resource/pubmed/id/12016099

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:12016099rdf:typepubmed:Citationlld:pubmed
pubmed-article:12016099lifeskim:mentionsumls-concept:C1445654lld:lifeskim
pubmed-article:12016099lifeskim:mentionsumls-concept:C0004048lld:lifeskim
pubmed-article:12016099lifeskim:mentionsumls-concept:C1280500lld:lifeskim
pubmed-article:12016099lifeskim:mentionsumls-concept:C1707455lld:lifeskim
pubmed-article:12016099lifeskim:mentionsumls-concept:C0205373lld:lifeskim
pubmed-article:12016099pubmed:issue10lld:pubmed
pubmed-article:12016099pubmed:dateCreated2002-5-17lld:pubmed
pubmed-article:12016099pubmed:abstractTextThe goal of this study was to establish a reliable method to evaluate systemic bioavailability and to determine equisystemic effects (microgram dose producing equal systemic cortisol suppression) of inhaled corticosteroids (ICS). Steroid naive asthma subjects (n = 156) were enrolled at six centers. A 1-week doubling dose design was used for each of six ICS and matched placebos for a total of four doses. Systemic effect was evaluated by hourly plasma cortisol concentrations (8 P.M. to 8 A.M.), 12- and 24-hour urine cortisol concentrations, and a morning blood osteocalcin. The area under the concentration-time curve for hourly cortisol concentrations was the best outcome variable to assess systemic effect. For the six ICS and matching placebos (beclomethasone-chlorofluorocarbon [CFC], budesonide dry powder inhaler [DPI], fluticasone DPI, fluticasone-CFC metered dose inhaler [MDI], flunisolide-CFC, and triamcinolone-CFC), only the placebo group and fluticasone DPI did not demonstrate a significant dose-response effect. Thus microgram comparison of all ICS could only be performed at a 10% cortisol suppression: flunisolide-CFC - 936; triamcinolone-CFC - 787; beclomethasone-CFC - 548; fluticasone DPI - 445; budesonide DPI - 268; fluticasone-CFC MDI - 111. This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis.lld:pubmed
pubmed-article:12016099pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:commentsCorrectionshttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:languageenglld:pubmed
pubmed-article:12016099pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:citationSubsetAIMlld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:12016099pubmed:statusMEDLINElld:pubmed
pubmed-article:12016099pubmed:monthMaylld:pubmed
pubmed-article:12016099pubmed:issn1073-449Xlld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:MartinRichard...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:DrazenJeffrey...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:FishJames EJElld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:PetersStephen...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:SzeflerStanle...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:FahyJohn VJVlld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:LemanskeRober...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:FordJean GJGlld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:ChinchilliVer...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:BousheyHomer...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:CherniackReub...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:CraigTimothy...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:DolovichMyrna...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:FaganJoanne...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:KraftMonicaMlld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:LazarusStephe...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:SorknessChris...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:IsraelElliott...lld:pubmed
pubmed-article:12016099pubmed:authorpubmed-author:KunselmanSusa...lld:pubmed
pubmed-article:12016099pubmed:issnTypePrintlld:pubmed
pubmed-article:12016099pubmed:day15lld:pubmed
pubmed-article:12016099pubmed:volume165lld:pubmed
pubmed-article:12016099pubmed:ownerNLMlld:pubmed
pubmed-article:12016099pubmed:authorsCompleteYlld:pubmed
pubmed-article:12016099pubmed:pagination1377-83lld:pubmed
pubmed-article:12016099pubmed:dateRevised2007-11-14lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:meshHeadingpubmed-meshheading:12016099...lld:pubmed
pubmed-article:12016099pubmed:year2002lld:pubmed
pubmed-article:12016099pubmed:articleTitleSystemic effect comparisons of six inhaled corticosteroid preparations.lld:pubmed
pubmed-article:12016099pubmed:affiliationNational Jewish Medical and Research Center, Denver, Colorado 80206, USA. martinr@njc.orglld:pubmed
pubmed-article:12016099pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:12016099pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:12016099pubmed:publicationTypeComparative Studylld:pubmed
pubmed-article:12016099pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
pubmed-article:12016099pubmed:publicationTypeRandomized Controlled Triallld:pubmed
pubmed-article:12016099pubmed:publicationTypeMulticenter Studylld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:12016099lld:pubmed
More...