| pubmed-article:11997503 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C1384567 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C0221284 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C2717951 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C1442792 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C1334871 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C1334870 | lld:lifeskim |
| pubmed-article:11997503 | lifeskim:mentions | umls-concept:C1314677 | lld:lifeskim |
| pubmed-article:11997503 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11997503 | pubmed:dateCreated | 2002-5-8 | lld:pubmed |
| pubmed-article:11997503 | pubmed:abstractText | The B-Myb transcription factor has been implicated in coordinating the expression of genes involved in cell cycle regulation. Although it is expressed in a ubiquitous manner, its transcriptional activity is repressed until the G(1)-S phase of the cell cycle by an unknown mechanism. In this study we used biochemical and cell-based assays to demonstrate that the nuclear receptor corepressors N-CoR and SMRT interact with B-Myb. The significance of these B-Myb-corepressor interactions was confirmed by the finding that B-Myb mutants, which were unable to bind N-CoR, exhibited constitutive transcriptional activity. It has been shown previously that phosphorylation of B-Myb by cdk2/cyclin A enhances its transcriptional activity. We have now determined that phosphorylation by cdk2/cyclin A blocks the interaction between B-Myb and N-CoR and that mutation of the corepressor binding site within B-Myb bypasses the requirement for this phosphorylation event. Cumulatively, these findings suggest that the nuclear corepressors N-CoR and SMRT serve a previously unappreciated role as regulators of B-Myb transcriptional activity. | lld:pubmed |
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| pubmed-article:11997503 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11997503 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11997503 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11997503 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11997503 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11997503 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11997503 | pubmed:author | pubmed-author:McDonnellDona... | lld:pubmed |
| pubmed-article:11997503 | pubmed:author | pubmed-author:LiXiaolinX | lld:pubmed |
| pubmed-article:11997503 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11997503 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:11997503 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11997503 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11997503 | pubmed:pagination | 3663-73 | lld:pubmed |
| pubmed-article:11997503 | pubmed:dateRevised | 2010-10-6 | lld:pubmed |
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