| pubmed-article:11986945 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11986945 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11986945 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11986945 | lifeskim:mentions | umls-concept:C0007587 | lld:lifeskim |
| pubmed-article:11986945 | lifeskim:mentions | umls-concept:C0039082 | lld:lifeskim |
| pubmed-article:11986945 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:11986945 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11986945 | pubmed:dateCreated | 2002-5-2 | lld:pubmed |
| pubmed-article:11986945 | pubmed:abstractText | In early stages of cutaneous T cell lymphoma (Sézary syndrome) both CD4+CD7- and CD4+CD7+ T cells clonally expand whereas in late stages of the disease CD7- cells are predominant in number, giving rise to the question whether CD7- T cells have a survival advantage in the skin. Galectin-1, a cell-bound lectin, was recently reported to trigger apoptosis in activated CD7+ T cells. Here, we demonstrate that in contrast to activated CD7(+) T cells, quiescent and activated CD69+ CD7- T cells from healthy donors and from Sézary patients are resistant to galectin-1-mediated cell death. CD7- T cells are apoptosis-resistant even during coculture with IFN-gamma-stimulated endothelial cells that constitutively express galectin-1 in high amounts. These data imply that resistance of CD7- T cells to galectin-1-induced apoptosis may contribute to the accumulation of CD7- Sézary T cells during progression of the disease. | lld:pubmed |
| pubmed-article:11986945 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11986945 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986945 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11986945 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986945 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986945 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986945 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986945 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11986945 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11986945 | pubmed:month | May | lld:pubmed |
| pubmed-article:11986945 | pubmed:issn | 0887-6924 | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:AndréSS | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:TilgenWW | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:SterryWW | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:AbkenHH | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:KaltnerHH | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:ReinholdUU | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:RappaHH | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:MucheJ MJM | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:UgurelSS | lld:pubmed |
| pubmed-article:11986945 | pubmed:author | pubmed-author:GabiusH-JHJ | lld:pubmed |
| pubmed-article:11986945 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11986945 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:11986945 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11986945 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11986945 | pubmed:pagination | 840-5 | lld:pubmed |
| pubmed-article:11986945 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11986945 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11986945 | pubmed:articleTitle | CD4+CD7- leukemic T cells from patients with Sézary syndrome are protected from galectin-1-triggered T cell death. | lld:pubmed |
| pubmed-article:11986945 | pubmed:affiliation | Department of Dermatology, The Saarland University Hospital, 66421 Homburg/Saar, Germany. | lld:pubmed |
| pubmed-article:11986945 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11986945 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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