Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2002-4-17
pubmed:abstractText
Members of the normally latent family of transcription factors signal/inducers and activators of transcription (Stat) are activated in a number of human tumors and tumor-derived cell lines. In the case of Stat3, it is believed that this activation leads to the induction of survival signals as well as increased proliferation. In this study, we demonstrate that Stat3 is constitutively activated in glioma and medulloblastoma tumors and that the activated protein localizes predominantly to the tumor endothelial cells in the highly vascularized glioma tumors. Our efforts to elucidate potential mechanism(s) for this activated protein have shown that coexpression of Stat3alpha and the vascular endothelial growth factor receptor-2 (VEGFR-2) result in ligand-independent activation of Stat3alpha tyrosine phosphorylation and subsequent transcriptional activation in non-endothelial cells. We also show that activated Stat3alpha can increase transcription from the vascular endothelial growth factor (VEGF) gene. Taken together, these results suggest that the activated Stat3alpha found in brain tumors may be due to the endothelial tyrosine kinase VEGFR-2 and that Stat3alpha may play a central role in autocrine VEGF activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2058-65
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:11960378-3T3 Cells, pubmed-meshheading:11960378-Animals, pubmed-meshheading:11960378-Brain Neoplasms, pubmed-meshheading:11960378-COS Cells, pubmed-meshheading:11960378-DNA-Binding Proteins, pubmed-meshheading:11960378-Electrophoretic Mobility Shift Assay, pubmed-meshheading:11960378-Endothelium, pubmed-meshheading:11960378-Gene Expression Regulation, Neoplastic, pubmed-meshheading:11960378-Glioma, pubmed-meshheading:11960378-Humans, pubmed-meshheading:11960378-Immunohistochemistry, pubmed-meshheading:11960378-Medulloblastoma, pubmed-meshheading:11960378-Mice, pubmed-meshheading:11960378-Phosphorylation, pubmed-meshheading:11960378-Phosphotyrosine, pubmed-meshheading:11960378-Receptor Protein-Tyrosine Kinases, pubmed-meshheading:11960378-Receptors, Growth Factor, pubmed-meshheading:11960378-Receptors, Vascular Endothelial Growth Factor, pubmed-meshheading:11960378-STAT3 Transcription Factor, pubmed-meshheading:11960378-Trans-Activators, pubmed-meshheading:11960378-Transcription, Genetic, pubmed-meshheading:11960378-Transcriptional Activation, pubmed-meshheading:11960378-Transfection
pubmed:year
2002
pubmed:articleTitle
Constitutive activation of Stat3alpha in brain tumors: localization to tumor endothelial cells and activation by the endothelial tyrosine kinase receptor (VEGFR-2).
pubmed:affiliation
Department of Neurosurgery, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, TX 77030, USA. tschaefe@mdanderson.org
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't