Source:http://linkedlifedata.com/resource/pubmed/id/11922140
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2002-3-29
|
| pubmed:abstractText |
Distinct sets of precursor cells generate the mammalian cerebral cortex. During neurogenesis most precursors are specified to generate a single cell type and only few are multipotent. The cell-intrinsic molecular determinants of these distinct lineages are not known. Here we describe that retroviral transduction of the transcription factor Emx2 in precursors from the cerebral cortex results in a significant increase of large clones that are generated mostly by symmetric cell divisions and contain multiple cell types, comprising neurons and glial cells. Thus, Emx2 is the first cell-intrinsic determinant able to instruct CNS precursors towards a multipotential fate. To evaluate the role of endogenous Emx2 in cortical precursors, we examined cell division in Emx2-/- mice. These analyses further supported the role of endogenous Emx2 in the regulation of symmetric cell divisions in the developing cortex.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1044-7431
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
485-502
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11922140-Animals,
pubmed-meshheading:11922140-Body Patterning,
pubmed-meshheading:11922140-Cell Death,
pubmed-meshheading:11922140-Cell Differentiation,
pubmed-meshheading:11922140-Cell Division,
pubmed-meshheading:11922140-Cell Lineage,
pubmed-meshheading:11922140-Cell Movement,
pubmed-meshheading:11922140-Cerebral Cortex,
pubmed-meshheading:11922140-Clone Cells,
pubmed-meshheading:11922140-Female,
pubmed-meshheading:11922140-Fetus,
pubmed-meshheading:11922140-Genes, Reporter,
pubmed-meshheading:11922140-Genetic Vectors,
pubmed-meshheading:11922140-Homeodomain Proteins,
pubmed-meshheading:11922140-Male,
pubmed-meshheading:11922140-Mice,
pubmed-meshheading:11922140-Mice, Knockout,
pubmed-meshheading:11922140-Mitosis,
pubmed-meshheading:11922140-Neuroglia,
pubmed-meshheading:11922140-Neurons,
pubmed-meshheading:11922140-Stem Cells,
pubmed-meshheading:11922140-Transcription Factors,
pubmed-meshheading:11922140-Transduction, Genetic
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Emx2 promotes symmetric cell divisions and a multipotential fate in precursors from the cerebral cortex.
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| pubmed:affiliation |
Max-Planck Institute for Neurobiology, Munich, Germany.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|