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pubmed-article:11917016pubmed:abstractTextWe report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.lld:pubmed
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pubmed-article:11917016pubmed:pagination1558-62lld:pubmed
pubmed-article:11917016pubmed:dateRevised2010-9-14lld:pubmed
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pubmed-article:11917016pubmed:articleTitleMultiple thiol-anchor capped DNA-gold nanoparticle conjugates.lld:pubmed
pubmed-article:11917016pubmed:affiliationNorthwestern University, Department of Chemistry and Institute for Nanotechnology, 2145 Sheridan Road, Evanston, IL 60208, USA.lld:pubmed
pubmed-article:11917016pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11917016pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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