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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2002-3-27
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pubmed:abstractText |
We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-10725107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-10815954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-10976070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-11101228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-11457171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-11457374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-11493092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-8757129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-8757130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-9262471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11917016-9358151
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1362-4962
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1558-62
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pubmed:dateRevised |
2010-9-14
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pubmed:meshHeading |
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pubmed:year |
2002
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pubmed:articleTitle |
Multiple thiol-anchor capped DNA-gold nanoparticle conjugates.
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pubmed:affiliation |
Northwestern University, Department of Chemistry and Institute for Nanotechnology, 2145 Sheridan Road, Evanston, IL 60208, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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