| pubmed-article:11903058 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11903058 | lifeskim:mentions | umls-concept:C0035143 | lld:lifeskim |
| pubmed-article:11903058 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:11903058 | lifeskim:mentions | umls-concept:C0206588 | lld:lifeskim |
| pubmed-article:11903058 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:11903058 | pubmed:issue | Pt 1 | lld:pubmed |
| pubmed-article:11903058 | pubmed:dateCreated | 2002-3-20 | lld:pubmed |
| pubmed-article:11903058 | pubmed:abstractText | The nuclear receptor corepressor (NCoR) was isolated as a peroxisome-proliferator-activated receptor (PPAR) delta interacting protein using the yeast two-hybrid system. NCoR interacted strongly with the ligand-binding domain of PPAR delta, whereas interactions with the ligand-binding domains of PPAR gamma and PPAR alpha were significantly weaker. PPAR-NCoR interactions were antagonized by ligands in the two-hybrid system, but were ligand-insensitive in in vitro pull-down assays. Interaction between PPAR delta and NCoR was unaffected by coexpression of retinoid X receptor (RXR) alpha. The PPAR delta-RXR alpha heterodimer bound to an acyl-CoA oxidase (ACO)-type peroxisome-proliferator response element recruited a glutathione S-transferase-NCoR fusion protein in a ligand-independent manner. Contrasting with most other nuclear receptors, PPAR delta was found to interact equally well with interaction domains I and II of NCoR. In transient transfection experiments, NCoR and the related silencing mediator for retinoid and thyroid hormone receptor (SMRT) were shown to exert a marked dose-dependent repression of ligand-induced PPAR delta-mediated transactivation; in addition, transactivation induced by the cAMP-elevating agent forskolin was efficiently reduced to basal levels by NCoR as well as SMRT coexpression. Our results suggest that the transactivation potential of liganded PPAR delta can be fine-tuned by interaction with NCoR and SMRT in a manner determined by the expression levels of corepressors and coactivators. | lld:pubmed |
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| pubmed-article:11903058 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11903058 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11903058 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11903058 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11903058 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11903058 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11903058 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:MandrupSusann... | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:KrogsdamAnne-... | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:NielsenCurt... | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:NeveSørenS | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:HolstDorteD | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:HelledieTorbe... | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:ThomsenBoB | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:BendixenChris... | lld:pubmed |
| pubmed-article:11903058 | pubmed:author | pubmed-author:KristiansenKa... | lld:pubmed |
| pubmed-article:11903058 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11903058 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11903058 | pubmed:volume | 363 | lld:pubmed |
| pubmed-article:11903058 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11903058 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11903058 | pubmed:pagination | 157-65 | lld:pubmed |
| pubmed-article:11903058 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:11903058 | pubmed:meshHeading | pubmed-meshheading:11903058... | lld:pubmed |
| pubmed-article:11903058 | pubmed:meshHeading | pubmed-meshheading:11903058... | lld:pubmed |
| pubmed-article:11903058 | pubmed:meshHeading | pubmed-meshheading:11903058... | lld:pubmed |
| pubmed-article:11903058 | pubmed:meshHeading | pubmed-meshheading:11903058... | lld:pubmed |
| pubmed-article:11903058 | pubmed:meshHeading | pubmed-meshheading:11903058... | lld:pubmed |
