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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2002-2-28
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pubmed:abstractText |
The lowest dose of aspirin shown to be effective in the secondary prevention of thrombotic accidents is 75 mg/day. Presystemic acetylation of cyclooxygenase and the formation of salicylic acid in the liver are fundamental to ensure optimum antithrombotic effects of aspirin. This study was designed to compare the effects of two forms of extended-release aspirin (at 75 mg/day) on prostanoid and nitric oxide synthesis in healthy volunteers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0031-6970
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
57
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
775-80
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11871383-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:11871383-Adult,
pubmed-meshheading:11871383-Arachidonic Acid,
pubmed-meshheading:11871383-Aspirin,
pubmed-meshheading:11871383-Blood Platelets,
pubmed-meshheading:11871383-Calcium,
pubmed-meshheading:11871383-Capsules,
pubmed-meshheading:11871383-Cross-Over Studies,
pubmed-meshheading:11871383-Delayed-Action Preparations,
pubmed-meshheading:11871383-Epoprostenol,
pubmed-meshheading:11871383-Female,
pubmed-meshheading:11871383-Humans,
pubmed-meshheading:11871383-Leukocytes,
pubmed-meshheading:11871383-Male,
pubmed-meshheading:11871383-Nitric Oxide,
pubmed-meshheading:11871383-Platelet Aggregation,
pubmed-meshheading:11871383-Platelet Aggregation Inhibitors,
pubmed-meshheading:11871383-Platelet Function Tests,
pubmed-meshheading:11871383-Prostaglandins,
pubmed-meshheading:11871383-Single-Blind Method
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pubmed:year |
2002
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pubmed:articleTitle |
Effects of two preparations of 75-mg extended-release aspirin on platelet aggregation, prostanoids and nitric oxide production in humans.
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pubmed:affiliation |
Department of Pharmacology and Therapeutics, School of Medicine, University of Málaga, Spain. jpcruz@uma.es
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
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