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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2002-2-22
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pubmed:abstractText |
Cytokines increase endothelial tissue factor (TF) and tissue plasminogen activator inhibitor type-1 (PAI-1) expression in vitro. Tissue factor interacts with factor VII to facilitate thrombosis and PAI-1 inhibits fibrinolysis by endogenous plasminogen activators. Because cytokine release is increased in children with sepsis-induced multiple organ failure (MOF), we hypothesized a cytokine associated increase in circulating TF and PAI-1 antigen release, and systemic activity in these patients.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0340-6245
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
87
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
218-23
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11858480-Adolescent,
pubmed-meshheading:11858480-Child,
pubmed-meshheading:11858480-Child, Preschool,
pubmed-meshheading:11858480-Cytokines,
pubmed-meshheading:11858480-Endothelium, Vascular,
pubmed-meshheading:11858480-Female,
pubmed-meshheading:11858480-Fibrinolysis,
pubmed-meshheading:11858480-Humans,
pubmed-meshheading:11858480-Infant,
pubmed-meshheading:11858480-Infant, Newborn,
pubmed-meshheading:11858480-Interleukin-6,
pubmed-meshheading:11858480-Male,
pubmed-meshheading:11858480-Multiple Organ Failure,
pubmed-meshheading:11858480-Nitrates,
pubmed-meshheading:11858480-Nitrites,
pubmed-meshheading:11858480-Pennsylvania,
pubmed-meshheading:11858480-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:11858480-Prospective Studies,
pubmed-meshheading:11858480-Sepsis,
pubmed-meshheading:11858480-Thrombophilia,
pubmed-meshheading:11858480-Thromboplastin
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pubmed:year |
2002
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pubmed:articleTitle |
The tissue factor and plasminogen activator inhibitor type-1 response in pediatric sepsis-induced multiple organ failure.
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pubmed:affiliation |
Department of Anesthesiology and Critical Care Medicine and Pediatrics, University of Pittsburgh School of Medicine, Pennsylvania, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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