| pubmed-article:11814846 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11814846 | lifeskim:mentions | umls-concept:C0003392 | lld:lifeskim |
| pubmed-article:11814846 | lifeskim:mentions | umls-concept:C0010868 | lld:lifeskim |
| pubmed-article:11814846 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:11814846 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11814846 | pubmed:dateCreated | 2002-1-29 | lld:pubmed |
| pubmed-article:11814846 | pubmed:abstractText | A methanolic crude extract of the plant Garuga pinnata Roxb. (Burseraceae) showed promising cytotoxic activity against a panel of human tumor cell lines in vitro, including KB and its drug-resistant sublines (Ferguson et al. Cancer Res. 1988, 48, 5956). Pheophorbide-a and-b methyl esters (3,4) were isolated as active principles with broad photo-dependent cytotoxic activities in the micromolar range. These findings prompted SAR studies of known and novel pheophorbide-a derivatives as photo-dependent and photo-independent cytotoxic agents. The results showed that zinc-protoporphyrin IX (10), zinc 13(R)-hydroxypheophorbide-a methyl ester (22), and zinc chlorin-e6 trimethyl ester (13) possessed photo-independent cytotoxic activity. Compounds 13 and 22 were the most active cytotoxic agents of the series (mean ED(50) 4.6 +/- 1.0 microM and 5.7 +/- 0.7 microM, respectively) against KB cells incubated in the dark. | lld:pubmed |
| pubmed-article:11814846 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11814846 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11814846 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11814846 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11814846 | pubmed:issn | 0968-0896 | lld:pubmed |
| pubmed-article:11814846 | pubmed:author | pubmed-author:BastowKenneth... | lld:pubmed |
| pubmed-article:11814846 | pubmed:author | pubmed-author:LeeKuo-Hsiung... | lld:pubmed |
| pubmed-article:11814846 | pubmed:author | pubmed-author:Wongsinkongma... | lld:pubmed |
| pubmed-article:11814846 | pubmed:author | pubmed-author:BrossiArnoldA | lld:pubmed |
| pubmed-article:11814846 | pubmed:author | pubmed-author:WangHui-KangH... | lld:pubmed |
| pubmed-article:11814846 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11814846 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:11814846 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11814846 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11814846 | pubmed:pagination | 583-91 | lld:pubmed |
| pubmed-article:11814846 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
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| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
| pubmed-article:11814846 | pubmed:meshHeading | pubmed-meshheading:11814846... | lld:pubmed |
| pubmed-article:11814846 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11814846 | pubmed:articleTitle | Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents. | lld:pubmed |
| pubmed-article:11814846 | pubmed:affiliation | Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599-7360, USA. | lld:pubmed |
| pubmed-article:11814846 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11814846 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11814846 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11814846 | lld:pubmed |
