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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2002-1-11
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pubmed:abstractText |
Unilateral ureteral obstruction (UUO) is characterized by proliferation of tubular and interstitial cells, and infiltration of the renal parenchyma with macrophages/monocytes. These alterations lead ultimately to tubulointerstitial fibrosis and tubular atrophy. Some of these changes are caused by an activated renin-angiotensin system (RAS). We have previously demonstrated that angiotensin II induces the expression of the cell cycle inhibitor p27KIP1 in cultured tubular cells. The current study tested the hypothesis that interference with the RAS may modulate renal expression of p27KIP1 after UUO.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
68-79
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11786086-Actins,
pubmed-meshheading:11786086-Angiotensin II,
pubmed-meshheading:11786086-Animals,
pubmed-meshheading:11786086-Apoptosis,
pubmed-meshheading:11786086-Blood Pressure,
pubmed-meshheading:11786086-Blotting, Western,
pubmed-meshheading:11786086-Cell Cycle,
pubmed-meshheading:11786086-Cell Cycle Proteins,
pubmed-meshheading:11786086-Cyclin-Dependent Kinase Inhibitor p27,
pubmed-meshheading:11786086-Gene Expression Regulation,
pubmed-meshheading:11786086-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:11786086-Immunohistochemistry,
pubmed-meshheading:11786086-In Situ Nick-End Labeling,
pubmed-meshheading:11786086-Kidney Cortex,
pubmed-meshheading:11786086-Male,
pubmed-meshheading:11786086-Nephritis, Interstitial,
pubmed-meshheading:11786086-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:11786086-Rats,
pubmed-meshheading:11786086-Rats, Sprague-Dawley,
pubmed-meshheading:11786086-Renin,
pubmed-meshheading:11786086-Renin-Angiotensin System,
pubmed-meshheading:11786086-Tumor Suppressor Proteins,
pubmed-meshheading:11786086-Ureteral Obstruction
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pubmed:year |
2002
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pubmed:articleTitle |
Induction of p27KIP1 after unilateral ureteral obstruction is independent of angiotensin II.
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pubmed:affiliation |
Klinik für Innere Medizin IV der Universität Jena, Germany. jk.gerth@t-online.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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