| pubmed-article:11777191 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11777191 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:11777191 | lifeskim:mentions | umls-concept:C1518419 | lld:lifeskim |
| pubmed-article:11777191 | lifeskim:mentions | umls-concept:C0021760 | lld:lifeskim |
| pubmed-article:11777191 | lifeskim:mentions | umls-concept:C0003123 | lld:lifeskim |
| pubmed-article:11777191 | lifeskim:mentions | umls-concept:C0065879 | lld:lifeskim |
| pubmed-article:11777191 | lifeskim:mentions | umls-concept:C0043096 | lld:lifeskim |
| pubmed-article:11777191 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:11777191 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11777191 | pubmed:dateCreated | 2002-1-4 | lld:pubmed |
| pubmed-article:11777191 | pubmed:abstractText | Megestrol acetate improves appetite and abrogates weight loss in some patients with advanced cancer. Moreover, preliminary studies suggest that progestational agents down-regulate interleukin-6 (IL-6), an inflammatory cytokine widely implicated in cancer-associated anorexia and weight loss. The present investigation examined the effects of megestrol acetate on IL-6 in an attempt to confirm these earlier, preliminary studies. The translational component of a large multi-institutional trial, this investigation examined 85 patients with advanced cancer and weight loss. Patients had been randomly assigned to receive megestrol acetate liquid suspension 800 mg/day + placebo tablets, or oral dronabinol tablets 2.5 mg b.i.d. + liquid placebo, or both agents. Other testing included serial physician-reported weight and patient-reported appetite and global quality of life. We found no significant differences in 1-month changes in serum IL-6 according to whether patients had been treated with megestrol acetate, dronabinol, or the combination: the mean differences +/- standard deviation were -1.52+/-4.7 pg/ml, -0.62+/-3.5 pg/ml, and -0.2+/-3.1 pg/ml, respectively (P=0.40, by one-way ANOVA). Among the patients who noted alterations in their appetite over 1 month, we observed no significant changes in IL-6. Finally, changes in serum IL-6 were not associated with shifts in weight or global quality of life. Our investigation provides no evidence that megestrol acetate down-regulates IL-6 in patients with cancer-associated anorexia and weight loss. | lld:pubmed |
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| pubmed-article:11777191 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11777191 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11777191 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11777191 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11777191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11777191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11777191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11777191 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11777191 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11777191 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11777191 | pubmed:issn | 0941-4355 | lld:pubmed |
| pubmed-article:11777191 | pubmed:author | pubmed-author:SloanJeff AJA | lld:pubmed |
| pubmed-article:11777191 | pubmed:author | pubmed-author:JatoiAminahA | lld:pubmed |
| pubmed-article:11777191 | pubmed:author | pubmed-author:YamashitaJun-... | lld:pubmed |
| pubmed-article:11777191 | pubmed:author | pubmed-author:NovotnyPaul... | lld:pubmed |
| pubmed-article:11777191 | pubmed:author | pubmed-author:WindschitlHar... | lld:pubmed |
| pubmed-article:11777191 | pubmed:author | pubmed-author:LoprinziCharl... | lld:pubmed |
| pubmed-article:11777191 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11777191 | pubmed:volume | 10 | lld:pubmed |
| pubmed-article:11777191 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11777191 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11777191 | pubmed:pagination | 71-5 | lld:pubmed |
| pubmed-article:11777191 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11777191 | pubmed:meshHeading | pubmed-meshheading:11777191... | lld:pubmed |
| pubmed-article:11777191 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11777191 | pubmed:articleTitle | Does megestrol acetate down-regulate interleukin-6 in patients with cancer-associated anorexia and weight loss? A North Central Cancer Treatment Group investigation. | lld:pubmed |
| pubmed-article:11777191 | pubmed:affiliation | Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA. Jatoi.aminah@mayo.edu | lld:pubmed |
| pubmed-article:11777191 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11777191 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11777191 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11777191 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11777191 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:11777191 | pubmed:publicationType | Multicenter Study | lld:pubmed |
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