|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0021469,
umls-concept:C0027950,
umls-concept:C0033634,
umls-concept:C0040715,
umls-concept:C0086418,
umls-concept:C0109289,
umls-concept:C0599718,
umls-concept:C0599813,
umls-concept:C0599893,
umls-concept:C1261322,
umls-concept:C1280500,
umls-concept:C1522702,
umls-concept:C1719914,
umls-concept:C2828406
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|
pubmed:issue |
11
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|
pubmed:dateCreated |
2001-12-17
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|
pubmed:abstractText |
The protein kinase C (PKC) is a serine/threonine kinase, consisting of different isoforms, implicated in numerous processes of signal transduction. To understand this enzyme well, different pharmacological tools were developed. To activate PKC specifically, phorbol esters were previously used but recent research has shown that these compounds are able to stimulate other proteins. Our model is the respiratory burst in the polymorphonuclear neutrophils. A decrease in the inflammatory process was measured using chelerythrine chloride. Action on PKC was proved by a binding study and by showing the absence of translocation of this enzyme from the cytoplasm to the plasmic membrane during stimulation.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-827X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
56
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
859-65
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11765038-Alkaloids,
pubmed-meshheading:11765038-Benzophenanthridines,
pubmed-meshheading:11765038-Enzyme Activation,
pubmed-meshheading:11765038-Enzyme Inhibitors,
pubmed-meshheading:11765038-Humans,
pubmed-meshheading:11765038-Isoenzymes,
pubmed-meshheading:11765038-Neutrophils,
pubmed-meshheading:11765038-Phenanthridines,
pubmed-meshheading:11765038-Protein Kinase C,
pubmed-meshheading:11765038-Protein Transport,
pubmed-meshheading:11765038-Respiratory Burst,
pubmed-meshheading:11765038-Signal Transduction,
pubmed-meshheading:11765038-Superoxides
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|
pubmed:year |
2001
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|
pubmed:articleTitle |
Investigation of the inhibitory effects of chelerythrine chloride on the translocation of the protein kinase C betaI, betaII, zeta in human neutrophils.
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pubmed:affiliation |
Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacologie, Pharmacocinétique et Pharmacie Cliniques, Lille, France.
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pubmed:publicationType |
Journal Article
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