| pubmed-article:11748160 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11748160 | lifeskim:mentions | umls-concept:C1411980 | lld:lifeskim |
| pubmed-article:11748160 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:11748160 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:11748160 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:11748160 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:11748160 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11748160 | pubmed:dateCreated | 2001-12-18 | lld:pubmed |
| pubmed-article:11748160 | pubmed:abstractText | Experimental infection of mice with a virulent strain of Mycobacterium avium leads to a slowly progressive disease, which we have previously shown culminates in loss of gamma interferon (IFN-gamma) production by T lymphocytes and death of the animals approximately 40 weeks after infection. Here we investigated the changes in T-cell activation, the production of interleukin-2 (IL-2), and the response to IL-2 throughout M. avium infection as a possible explanation for this loss. We found that there is a steady increase in the percentage of T cells expressing activation markers right to the end of infection. However, in vivo T-cell proliferation, measured as a percentage of CD4(+) and CD8(+) cells incorporating 5-bromo-2'-deoxyuridine, initially increased but then remained constant. In the final stages of infection there was a decline in proliferation of activated (CD62L(-)) T cells. Since IL-2 is a major driver of T-cell proliferation, we asked whether this was due to loss of IL-2 responsiveness or production. However, CD25 (IL-2Ralpha) continued to be highly expressed in the terminal stages of infection, and although IL-2 production declined, addition of recombinant IL-2 to cultures could not rescue the final loss of IFN-gamma production. | lld:pubmed |
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| pubmed-article:11748160 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11748160 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11748160 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11748160 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11748160 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11748160 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11748160 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:11748160 | pubmed:author | pubmed-author:ManneringStua... | lld:pubmed |
| pubmed-article:11748160 | pubmed:author | pubmed-author:CheersChristi... | lld:pubmed |
| pubmed-article:11748160 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11748160 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:11748160 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11748160 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11748160 | pubmed:pagination | 27-35 | lld:pubmed |
| pubmed-article:11748160 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11748160 | pubmed:meshHeading | pubmed-meshheading:11748160... | lld:pubmed |
| pubmed-article:11748160 | pubmed:year | 2002 | lld:pubmed |
| pubmed-article:11748160 | pubmed:articleTitle | Interleukin-2 and loss of immunity in experimental Mycobacterium avium infection. | lld:pubmed |
| pubmed-article:11748160 | pubmed:affiliation | Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia. mannering@wehi.edu.au | lld:pubmed |
| pubmed-article:11748160 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11748160 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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