Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-12-18
pubmed:abstractText
Experimental infection of mice with a virulent strain of Mycobacterium avium leads to a slowly progressive disease, which we have previously shown culminates in loss of gamma interferon (IFN-gamma) production by T lymphocytes and death of the animals approximately 40 weeks after infection. Here we investigated the changes in T-cell activation, the production of interleukin-2 (IL-2), and the response to IL-2 throughout M. avium infection as a possible explanation for this loss. We found that there is a steady increase in the percentage of T cells expressing activation markers right to the end of infection. However, in vivo T-cell proliferation, measured as a percentage of CD4(+) and CD8(+) cells incorporating 5-bromo-2'-deoxyuridine, initially increased but then remained constant. In the final stages of infection there was a decline in proliferation of activated (CD62L(-)) T cells. Since IL-2 is a major driver of T-cell proliferation, we asked whether this was due to loss of IL-2 responsiveness or production. However, CD25 (IL-2Ralpha) continued to be highly expressed in the terminal stages of infection, and although IL-2 production declined, addition of recombinant IL-2 to cultures could not rescue the final loss of IFN-gamma production.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10352292, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10358758, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10377097, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10377146, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10438946, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10768995, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10858244, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10880532, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-10952725, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-1588283, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-1649796, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-2939169, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-2955050, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-5127141, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-5706694, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-6376356, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-6386183, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-7513305, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-7529749, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-7768610, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-7790028, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-8145034, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-8216925, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-8791716, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-9108081, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-9127888, http://linkedlifedata.com/resource/pubmed/commentcorrection/11748160-9713647
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-35
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:11748160-Animals, pubmed-meshheading:11748160-Antigens, CD44, pubmed-meshheading:11748160-Biological Markers, pubmed-meshheading:11748160-CD4-Positive T-Lymphocytes, pubmed-meshheading:11748160-CD8-Positive T-Lymphocytes, pubmed-meshheading:11748160-Cell Division, pubmed-meshheading:11748160-Disease Models, Animal, pubmed-meshheading:11748160-Female, pubmed-meshheading:11748160-Humans, pubmed-meshheading:11748160-Interleukin-2, pubmed-meshheading:11748160-L-Selectin, pubmed-meshheading:11748160-Lymphocyte Activation, pubmed-meshheading:11748160-Mice, pubmed-meshheading:11748160-Mice, Inbred C57BL, pubmed-meshheading:11748160-Mycobacterium avium Complex, pubmed-meshheading:11748160-Mycobacterium avium-intracellulare Infection, pubmed-meshheading:11748160-Receptors, Interleukin-2, pubmed-meshheading:11748160-Spleen, pubmed-meshheading:11748160-T-Lymphocytes
pubmed:year
2002
pubmed:articleTitle
Interleukin-2 and loss of immunity in experimental Mycobacterium avium infection.
pubmed:affiliation
Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia. mannering@wehi.edu.au
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't