Linked Life Data

11734362

Source:http://linkedlifedata.com/resource/pubmed/id/11734362

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-12-5
pubmed:abstractText
Information processing and attentional abnormalities are prominent in neuropsychiatric disorders. Since the cholinergic neurons located in the nucleus basalis magnocellularis have been shown to be involved in attentional performance and information processing, recent efforts to analyze the significance of the basal forebrain in the context of schizophrenia have focused on this nucleus and its projections to the cerebral cortex. We report here that bilateral selective immunolesioning of the cholinergic neurons in the nucleus basalis magnocellularis is followed by significant deficits in sensorimotor gating measured by prepulse inhibition of the startle reflex in adult rats. This behavioral approach is used in both humans and rodents and has been proposed as a valuable model contributing to the understanding of the neurobiological substrates of schizophrenia. The disruption of prepulse inhibition persisted over repeated testing. The selective lesions were induced by bilateral intraparenchymal infusions of 192 IgG saporin at a concentration having minimal diffusion into adjacent nuclei of the basal forebrain. The infusions were followed by extensive loss of choline acetyltransferase-immunopositive neurons. Our results show that the cholinergic neurons of the nucleus basalis magnocellularis represent a critical station of the startle gating circuitry and suggest that dysfunction of these neurons may result in impaired sensorimotor gating characteristic of schizophrenia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-4522
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-305
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:11734362-Acetylcholine, pubmed-meshheading:11734362-Animals, pubmed-meshheading:11734362-Antibodies, Monoclonal, pubmed-meshheading:11734362-Basal Nucleus of Meynert, pubmed-meshheading:11734362-Behavior, Animal, pubmed-meshheading:11734362-Cerebral Cortex, pubmed-meshheading:11734362-Choline O-Acetyltransferase, pubmed-meshheading:11734362-Cholinergic Agents, pubmed-meshheading:11734362-Cholinergic Fibers, pubmed-meshheading:11734362-Immunohistochemistry, pubmed-meshheading:11734362-Immunotoxins, pubmed-meshheading:11734362-Male, pubmed-meshheading:11734362-N-Glycosyl Hydrolases, pubmed-meshheading:11734362-Nerve Degeneration, pubmed-meshheading:11734362-Neural Inhibition, pubmed-meshheading:11734362-Neural Pathways, pubmed-meshheading:11734362-Neurons, pubmed-meshheading:11734362-Rats, pubmed-meshheading:11734362-Rats, Sprague-Dawley, pubmed-meshheading:11734362-Ribosome Inactivating Proteins, Type 1, pubmed-meshheading:11734362-Schizophrenia, pubmed-meshheading:11734362-Startle Reaction
pubmed:year
2001
pubmed:articleTitle
Selective immunolesioning of cholinergic neurons in nucleus basalis magnocellularis impairs prepulse inhibition of acoustic startle.
pubmed:affiliation
Department of Biomedical Sciences and Biotechnologies, Brescia University Mecial School, Italy. mballm@med.unibs.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't