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rdf:type |
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lifeskim:mentions |
umls-concept:C0015576,
umls-concept:C0017262,
umls-concept:C0023675,
umls-concept:C0030498,
umls-concept:C0033640,
umls-concept:C0085328,
umls-concept:C0185117,
umls-concept:C0205314,
umls-concept:C0243045,
umls-concept:C0679622,
umls-concept:C0683941,
umls-concept:C1514562,
umls-concept:C1521970,
umls-concept:C2700640,
umls-concept:C2911684
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pubmed:issue |
2
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pubmed:dateCreated |
2001-12-4
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pubmed:databankReference |
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pubmed:abstractText |
The TaCRK3 gene from the bovine apicomplexan parasite Theileria annulata, encodes a 46 kDa polypeptide with strong homology to the eukaryotic family of cyclin-dependent kinases. TaCRK3 does not show significant alignment with any particular CDK group, other than the Pfmrk kinases from the related apicomplexans Plasmodium falciparum and Plasmodium yoelii. It has a putative bipartite nuclear localization signal and is located to parasite nuclei by IFAT. Protein levels are constitutive throughout differentiation of the intra-lymphocytic macroschizont. This contrasts with the expression pattern of TaCRK2 (Kinnaird et al., 1996, Mol. Microbiol., 22, 293-302) which is closely related to the eukaryotic CDK1 /2 families involved in regulation of cell cycle progression. TaCRK2 is also located to the parasite nuclei but has no nuclear localization signal and exhibits transient up-regulation in protein levels during mid-merogony. However compared to TaCRK3, it shows down-regulation near the end of merogony. We predict that TaCRK3 may have a role in regulation of gene transcription while TaCRK2 is more likely to be involved in control of parasite nuclear division.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CDC2 Protein Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/CRK protein, protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/CRK3 kinase, protozoa,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclin-Dependent Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Protozoan
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0378-1119
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
279
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
127-35
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11733137-Amino Acid Motifs,
pubmed-meshheading:11733137-Amino Acid Sequence,
pubmed-meshheading:11733137-Animals,
pubmed-meshheading:11733137-Blotting, Northern,
pubmed-meshheading:11733137-CDC2 Protein Kinase,
pubmed-meshheading:11733137-Cattle,
pubmed-meshheading:11733137-Cell Line,
pubmed-meshheading:11733137-Cyclin-Dependent Kinases,
pubmed-meshheading:11733137-DNA, Complementary,
pubmed-meshheading:11733137-Eukaryotic Cells,
pubmed-meshheading:11733137-Gene Expression Regulation, Developmental,
pubmed-meshheading:11733137-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:11733137-Molecular Sequence Data,
pubmed-meshheading:11733137-Protein Kinases,
pubmed-meshheading:11733137-Protozoan Proteins,
pubmed-meshheading:11733137-RNA, Protozoan,
pubmed-meshheading:11733137-Sequence Alignment,
pubmed-meshheading:11733137-Sequence Analysis, DNA,
pubmed-meshheading:11733137-Sequence Homology, Amino Acid,
pubmed-meshheading:11733137-Theileria annulata,
pubmed-meshheading:11733137-Theileriasis
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pubmed:year |
2001
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pubmed:articleTitle |
TaCRK3 encodes a novel Theileria annulata protein kinase with motifs characteristic of the family of eukaryotic cyclin dependent kinases: a comparative analysis of its expression with TaCRK2 during the parasite life cycle.
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pubmed:affiliation |
Department of Veterinary Parasitology, Glasgow University, Bearsden Road, Glasgow G61 1QH, UK. j.kinnaird@vet.gla.ac.uk
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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