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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-12-3
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pubmed:abstractText |
HIV nephropathy (HIVAN) is markedly racially biased in its distribution, occurring in about 10% of HIV infected African Americans according to some studies. Based upon previous laboratory and epidemiological studies, the Duffy promoter polymorphism, which occurs almost exclusively in individuals of African descent, has been postulated to be the predisposing factor. We aimed to explore that relationship by directly genotyping individuals with HIV nephropathy to determine the proportion homozygous for this mutation to test the hypothesis it was responsible for the genetic component of this disease. We anticipated that if the polymorphism was associated with HIV nephropathy all individuals would be homozygous for this mutation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
1121-8428
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
384-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11730271-AIDS-Associated Nephropathy,
pubmed-meshheading:11730271-Adult,
pubmed-meshheading:11730271-African Continental Ancestry Group,
pubmed-meshheading:11730271-Antigens, Protozoan,
pubmed-meshheading:11730271-Carrier Proteins,
pubmed-meshheading:11730271-Female,
pubmed-meshheading:11730271-Genetic Predisposition to Disease,
pubmed-meshheading:11730271-Humans,
pubmed-meshheading:11730271-Kidney,
pubmed-meshheading:11730271-Male,
pubmed-meshheading:11730271-Polymorphism, Genetic,
pubmed-meshheading:11730271-Promoter Regions, Genetic,
pubmed-meshheading:11730271-Protozoan Proteins,
pubmed-meshheading:11730271-Receptors, Cell Surface,
pubmed-meshheading:11730271-Retrospective Studies,
pubmed-meshheading:11730271-Sequence Analysis, DNA,
pubmed-meshheading:11730271-United States
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pubmed:articleTitle |
HIV nephropathy and the Duffy antigen/receptor for Chemokines in African Americans.
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pubmed:affiliation |
Department of Medicine, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA. ianwoolley@hotmail.com
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pubmed:publicationType |
Journal Article
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