| pubmed-article:11728181 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11728181 | lifeskim:mentions | umls-concept:C1533646 | lld:lifeskim |
| pubmed-article:11728181 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:11728181 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:11728181 | lifeskim:mentions | umls-concept:C0043309 | lld:lifeskim |
| pubmed-article:11728181 | lifeskim:mentions | umls-concept:C2267219 | lld:lifeskim |
| pubmed-article:11728181 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:11728181 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:11728181 | lifeskim:mentions | umls-concept:C1707689 | lld:lifeskim |
| pubmed-article:11728181 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:11728181 | pubmed:dateCreated | 2001-11-30 | lld:pubmed |
| pubmed-article:11728181 | pubmed:abstractText | Two closely related classes of oxindole-based compounds, 1H-indole-2,3-dione 3-phenylhydrazones and 3-(anilinomethylene)-1,3-dihydro-2H-indol-2-ones, were shown to potently inhibit cyclin-dependent kinase 2 (CDK2). The initial lead compound was prepared as a homologue of the 3-benzylidene-1,3-dihydro-2H-indol-2-one class of kinase inhibitor. Crystallographic analysis of the lead compound bound to CDK2 provided the basis for analogue design. A semiautomated method of ligand docking was used to select compounds for synthesis, and a number of compounds with low nanomolar inhibitory activity versus CDK2 were identified. Enzyme binding determinants for several analogues were evaluated by X-ray crystallography. Compounds in this series inhibited CDK2 with a potency approximately 10-fold greater than that for CDK1. Members of this class of inhibitor cause an arrest of the cell cycle and have shown potential utility in the prevention of chemotherapy-induced alopecia. | lld:pubmed |
| pubmed-article:11728181 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11728181 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11728181 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11728181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11728181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11728181 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11728181 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11728181 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11728181 | pubmed:issn | 0022-2623 | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:WalkerD HDH | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:HarrisP APA | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:BramsonH NHN | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:EdelsteinMM | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:MontaniNN | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:KuyperL FLF | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:LovejoyBB | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:VealJ MJM | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:RocqueW JWJ | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:ShewchukLL | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:HassellAA | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:GampeR TRTJr | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:DavisS TST | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:CoronaJJ | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:HunterR NRN | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:FryeS VSV | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:LuzzioM JMJ | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:DickersonS... | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:HolmesW DWD | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:LackeyK EKE | lld:pubmed |
| pubmed-article:11728181 | pubmed:author | pubmed-author:RusnakDD | lld:pubmed |
| pubmed-article:11728181 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11728181 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:11728181 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:11728181 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11728181 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11728181 | pubmed:pagination | 4339-58 | lld:pubmed |
| pubmed-article:11728181 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11728181 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11728181 | pubmed:articleTitle | Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis. | lld:pubmed |
| pubmed-article:11728181 | pubmed:affiliation | GlaxoSmithKline Inc., Five Moore Drive, Research Triangle Park, North Carolina 27709, USA. | lld:pubmed |
| pubmed-article:11728181 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:11728181 | lld:chembl |
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