Linked Life Data

11717367

Source:http://linkedlifedata.com/resource/pubmed/id/11717367

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
23
pubmed:dateCreated
2001-11-21
pubmed:abstractText
Little axonal regeneration occurs after spinal cord injury in adult mammals. Regrowth of mature CNS axons can be induced, however, by altering the intrinsic capacity of the neurons for growth or by providing a permissive environment at the injury site. Fetal spinal cord transplants and neurotrophins were used to influence axonal regeneration in the adult rat after complete spinal cord transection at a midthoracic level. Transplants were placed into the lesion cavity either immediately after transection (acute injury) or after a 2-4 week delay (delayed or chronic transplants), and either vehicle or neurotrophic factors were administered exogenously via an implanted minipump. Host axons grew into the transplant in all groups. Surprisingly, regeneration from supraspinal pathways and recovery of motor function were dramatically increased when transplants and neurotrophins were delayed until 2-4 weeks after transection rather than applied acutely. Axonal growth back into the spinal cord below the lesion and transplants was seen only in the presence of neurotrophic factors. Furthermore, the restoration of anatomical connections across the injury site was associated with recovery of function with animals exhibiting plantar foot placement and weight-supported stepping. These findings suggest that the opportunity for intervention after spinal cord injury may be greater than originally envisioned and that CNS neurons with long-standing injuries can reinitiate growth, leading to improvement in motor function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
21
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9334-44
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11717367-Animals, pubmed-meshheading:11717367-Axons, pubmed-meshheading:11717367-Axotomy, pubmed-meshheading:11717367-Behavior, Animal, pubmed-meshheading:11717367-Brain-Derived Neurotrophic Factor, pubmed-meshheading:11717367-Dextrans, pubmed-meshheading:11717367-Disease Models, Animal, pubmed-meshheading:11717367-Female, pubmed-meshheading:11717367-Fetal Tissue Transplantation, pubmed-meshheading:11717367-Fluorescent Dyes, pubmed-meshheading:11717367-Hindlimb, pubmed-meshheading:11717367-Locomotion, pubmed-meshheading:11717367-Motor Activity, pubmed-meshheading:11717367-Nerve Growth Factors, pubmed-meshheading:11717367-Nerve Tissue, pubmed-meshheading:11717367-Neurotrophin 3, pubmed-meshheading:11717367-Rats, pubmed-meshheading:11717367-Rats, Sprague-Dawley, pubmed-meshheading:11717367-Recovery of Function, pubmed-meshheading:11717367-Rhodamines, pubmed-meshheading:11717367-Spinal Cord, pubmed-meshheading:11717367-Spinal Cord Injuries, pubmed-meshheading:11717367-Stilbamidines, pubmed-meshheading:11717367-Time Factors, pubmed-meshheading:11717367-Treatment Outcome
pubmed:year
2001
pubmed:articleTitle
Axonal regeneration and functional recovery after complete spinal cord transection in rats by delayed treatment with transplants and neurotrophins.
pubmed:affiliation
Department of Neuroscience, Georgetown University Medical Center, Washington, DC 20007, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't