| pubmed-article:11689945 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11689945 | lifeskim:mentions | umls-concept:C0022023 | lld:lifeskim |
| pubmed-article:11689945 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:11689945 | lifeskim:mentions | umls-concept:C0457405 | lld:lifeskim |
| pubmed-article:11689945 | pubmed:issue | 6859 | lld:pubmed |
| pubmed-article:11689945 | pubmed:dateCreated | 2001-11-5 | lld:pubmed |
| pubmed-article:11689945 | pubmed:abstractText | K+ channels are transmembrane proteins that are essential for the transmission of nerve impulses. The ability of these proteins to conduct K+ ions at levels near the limit of diffusion is traditionally described in terms of concerted mechanisms in which ion-channel attraction and ion-ion repulsion have compensating effects, as several ions are moving simultaneously in single file through the narrow pore. The efficiency of such a mechanism, however, relies on a delicate energy balance-the strong ion-channel attraction must be perfectly counterbalanced by the electrostatic ion-ion repulsion. To elucidate the mechanism of ion conduction at the atomic level, we performed molecular dynamics free energy simulations on the basis of the X-ray structure of the KcsA K+ channel. Here we find that ion conduction involves transitions between two main states, with two and three K+ ions occupying the selectivity filter, respectively; this process is reminiscent of the 'knock-on' mechanism proposed by Hodgkin and Keynes in 1955. The largest free energy barrier is on the order of 2-3 kcal mol-1, implying that the process of ion conduction is limited by diffusion. Ion-ion repulsion, although essential for rapid conduction, is shown to act only at very short distances. The calculations show also that the rapidly conducting pore is selective. | lld:pubmed |
| pubmed-article:11689945 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11689945 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11689945 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11689945 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11689945 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11689945 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11689945 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11689945 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:11689945 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:11689945 | pubmed:author | pubmed-author:RouxBB | lld:pubmed |
| pubmed-article:11689945 | pubmed:author | pubmed-author:BernècheSS | lld:pubmed |
| pubmed-article:11689945 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11689945 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11689945 | pubmed:volume | 414 | lld:pubmed |
| pubmed-article:11689945 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11689945 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11689945 | pubmed:pagination | 73-7 | lld:pubmed |
| pubmed-article:11689945 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11689945 | pubmed:meshHeading | pubmed-meshheading:11689945... | lld:pubmed |
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| pubmed-article:11689945 | pubmed:meshHeading | pubmed-meshheading:11689945... | lld:pubmed |
| pubmed-article:11689945 | pubmed:meshHeading | pubmed-meshheading:11689945... | lld:pubmed |
| pubmed-article:11689945 | pubmed:meshHeading | pubmed-meshheading:11689945... | lld:pubmed |
| pubmed-article:11689945 | pubmed:meshHeading | pubmed-meshheading:11689945... | lld:pubmed |
| pubmed-article:11689945 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11689945 | pubmed:articleTitle | Energetics of ion conduction through the K+ channel. | lld:pubmed |
| pubmed-article:11689945 | pubmed:affiliation | Department of Biochemistry, Weill Medical College of Cornell University, New York, New York 10021, USA. | lld:pubmed |
| pubmed-article:11689945 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11689945 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11689945 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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