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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2001-11-5
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pubmed:abstractText |
Activation of group 1 metabotropic glutamate receptors (mGluRs) stimulates dendritic protein synthesis and long-term synaptic depression (LTD), but it remains unclear how these effects are related. Here we provide evidence that a consequence of mGluR activation in the hippocampus is the rapid loss of both AMPA and NMDA receptors from synapses. Like mGluR-LTD, the stable expression of this change requires protein synthesis. These data suggest that expression of mGluR-LTD is at least partly postsynaptic, and that a functional consequence of dendritic protein synthesis is the regulation of glutamate receptor trafficking.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3,5-dihydroxyphenylglycine,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Cycloheximide,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Glycine,
http://linkedlifedata.com/resource/pubmed/chemical/LY 341495,
http://linkedlifedata.com/resource/pubmed/chemical/Methoxyhydroxyphenylglycol,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, AMPA,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Metabotropic Glutamate,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/Resorcinols,
http://linkedlifedata.com/resource/pubmed/chemical/Synapsins,
http://linkedlifedata.com/resource/pubmed/chemical/Xanthenes,
http://linkedlifedata.com/resource/pubmed/chemical/dihydroxyphenylethylene glycol
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1079-85
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pubmed:dateRevised |
2011-9-22
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pubmed:meshHeading |
pubmed-meshheading:11687813-Amino Acids,
pubmed-meshheading:11687813-Animals,
pubmed-meshheading:11687813-Cells, Cultured,
pubmed-meshheading:11687813-Cycloheximide,
pubmed-meshheading:11687813-Dendrites,
pubmed-meshheading:11687813-Electrophysiology,
pubmed-meshheading:11687813-Endocytosis,
pubmed-meshheading:11687813-Excitatory Amino Acid Antagonists,
pubmed-meshheading:11687813-Excitatory Postsynaptic Potentials,
pubmed-meshheading:11687813-Glycine,
pubmed-meshheading:11687813-Hippocampus,
pubmed-meshheading:11687813-Immunohistochemistry,
pubmed-meshheading:11687813-Methoxyhydroxyphenylglycol,
pubmed-meshheading:11687813-Neurons,
pubmed-meshheading:11687813-Protein Synthesis Inhibitors,
pubmed-meshheading:11687813-Rats,
pubmed-meshheading:11687813-Rats, Long-Evans,
pubmed-meshheading:11687813-Receptors, AMPA,
pubmed-meshheading:11687813-Receptors, Metabotropic Glutamate,
pubmed-meshheading:11687813-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:11687813-Resorcinols,
pubmed-meshheading:11687813-Synapses,
pubmed-meshheading:11687813-Synapsins,
pubmed-meshheading:11687813-Synaptic Transmission,
pubmed-meshheading:11687813-Xanthenes
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pubmed:year |
2001
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pubmed:articleTitle |
Internalization of ionotropic glutamate receptors in response to mGluR activation.
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pubmed:affiliation |
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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