| pubmed-article:11686836 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11686836 | lifeskim:mentions | umls-concept:C0009319 | lld:lifeskim |
| pubmed-article:11686836 | lifeskim:mentions | umls-concept:C0009368 | lld:lifeskim |
| pubmed-article:11686836 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:11686836 | lifeskim:mentions | umls-concept:C0221198 | lld:lifeskim |
| pubmed-article:11686836 | lifeskim:mentions | umls-concept:C0205178 | lld:lifeskim |
| pubmed-article:11686836 | lifeskim:mentions | umls-concept:C1819464 | lld:lifeskim |
| pubmed-article:11686836 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11686836 | lifeskim:mentions | umls-concept:C0535734 | lld:lifeskim |
| pubmed-article:11686836 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11686836 | pubmed:dateCreated | 2001-11-5 | lld:pubmed |
| pubmed-article:11686836 | pubmed:abstractText | Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are believed to play a significant role in the pathogenesis of inflammatory bowel disease (IBD). Interleukin-1 and TNF-alpha possess overlapping and synergetic activities inducing the production in cascade of other cytokines, adhesion molecules, arachidonic acid metabolites, as well as activating immune and non-immune cells. FR167653 (C24H18FN5O2-H2SO4-H2O) is a newly synthesized organic compound with a potent inhibitory effect on IL-1beta and TNF-alpha production. We hypothesized that the suppression of IL-1 and TNF-alpha induced by FR167653 could effectively attenuate experimentally induced colonic damage. | lld:pubmed |
| pubmed-article:11686836 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11686836 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11686836 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11686836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11686836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11686836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11686836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11686836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11686836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11686836 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11686836 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11686836 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11686836 | pubmed:issn | 0815-9319 | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:SatoTT | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:WatanabeSS | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:KatoSS | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:KomatsuKK | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:KonishiNN | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:OtakaMM | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:JinMM | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:OdashimaMM | lld:pubmed |
| pubmed-article:11686836 | pubmed:author | pubmed-author:BlandinoI III | lld:pubmed |
| pubmed-article:11686836 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11686836 | pubmed:volume | 16 | lld:pubmed |
| pubmed-article:11686836 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11686836 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11686836 | pubmed:pagination | 1105-11 | lld:pubmed |
| pubmed-article:11686836 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:meshHeading | pubmed-meshheading:11686836... | lld:pubmed |
| pubmed-article:11686836 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11686836 | pubmed:articleTitle | FR167653, a potent suppressant of interleukin-1 and tumor necrosis factor-alpha production, ameliorates colonic lesions in experimentally induced acute colitis. | lld:pubmed |
| pubmed-article:11686836 | pubmed:affiliation | First Department of Internal Medicine, Akita University School of Medicine, Akita City, Akita, Japan. | lld:pubmed |
| pubmed-article:11686836 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11686836 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11686836 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11686836 | lld:pubmed |
