Source:http://linkedlifedata.com/resource/pubmed/id/11682400
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2001-10-29
|
| pubmed:abstractText |
We studied 160 ASA I or II patients undergoing elective otolaryngologic surgery in order to compare the anxiolytic effects of a novel 5-hydroxytryptamine-1A agonist, tandospirone, with diazepam. To monitor preoperative anxiety, the following variables were used: systolic and diastolic arterial pressure, heart rate, and the state anxiety score yielded by the Spielberger State-Trait Anxiety Inventory. We performed pretreatment evaluation on the day before surgery and posttreatment examination immediately after entry into the operating room. In a double-blinded, randomized design, four groups of 40 patients each received one of the following oral medications 90 min before entry into the operating room: 1) tandospirone 10 mg (T10 group); 2) tandospirone 30 mg (T30 group); 3) diazepam 10 mg (D group); or 4) placebo (P group). After premedication, the State-Trait Anxiety Inventory state anxiety decreased in the T10 (P < 0.02), T30 (P < 0.02), and D groups (P < 0.001), but it increased in the P group (P < 0.001). Tandospirone, 10 and 30 mg, safely reduced preoperative anxiety to a similar extent as oral diazepam 10 mg in patients undergoing elective otolaryngologic surgery. IMPLICATIONS: Oral tandospirone reduces preoperative anxiety to a similar extent as oral diazepam in patients undergoing elective otolaryngologic surgery. This finding implies that tandospirone can be used as an oral premedicant drug for relieving anxiety before surgery.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Anxiety Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Diazepam,
http://linkedlifedata.com/resource/pubmed/chemical/Isoindoles,
http://linkedlifedata.com/resource/pubmed/chemical/Piperazines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin, 5-HT1,
http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Receptor Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/tandospirone
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0003-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
93
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1214-6
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:11682400-Adolescent,
pubmed-meshheading:11682400-Adult,
pubmed-meshheading:11682400-Anti-Anxiety Agents,
pubmed-meshheading:11682400-Anxiety,
pubmed-meshheading:11682400-Blood Pressure,
pubmed-meshheading:11682400-Diazepam,
pubmed-meshheading:11682400-Double-Blind Method,
pubmed-meshheading:11682400-Female,
pubmed-meshheading:11682400-Heart Rate,
pubmed-meshheading:11682400-Humans,
pubmed-meshheading:11682400-Isoindoles,
pubmed-meshheading:11682400-Male,
pubmed-meshheading:11682400-Middle Aged,
pubmed-meshheading:11682400-Otorhinolaryngologic Surgical Procedures,
pubmed-meshheading:11682400-Piperazines,
pubmed-meshheading:11682400-Preoperative Care,
pubmed-meshheading:11682400-Pyrimidines,
pubmed-meshheading:11682400-Receptors, Serotonin,
pubmed-meshheading:11682400-Receptors, Serotonin, 5-HT1,
pubmed-meshheading:11682400-Serotonin Receptor Agonists
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
The anxiolytic effects of the 5-hydroxytryptamine-1A agonist tandospirone before otolaryngologic surgery.
|
| pubmed:affiliation |
Department of Anesthesiology and Critical Care Medicine, Gifu University School of Medicine, Gifu, Japan. oshimat@cc.gifu-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|