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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1975-6-20
|
| pubmed:abstractText |
The S isomer of Ftorafur was synthesized and the ability of the latter to inhibit growth of cultured human fibroblasts was determined relative to both the R isomer and the racemic mixture (Ftorafur) that is presently used clinically. No significant difference in the cytotoxic effects or the relative abilities to prevent an increase in cell numbers was observed with the three forms. Inhibition of DNA synthesis in murine L1210 leukemia cells by either isomer was observed only after prolonged (18-hr) exposure. The data suggest that Ftorafur is a repository form of 5-fluorouracil and that activity is manifested equally by both isomers.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0008-5472
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1301-4
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1168096-Animals,
pubmed-meshheading:1168096-Cell Division,
pubmed-meshheading:1168096-Cells, Cultured,
pubmed-meshheading:1168096-DNA, Neoplasm,
pubmed-meshheading:1168096-Deoxyuridine,
pubmed-meshheading:1168096-Fibroblasts,
pubmed-meshheading:1168096-Fluorouracil,
pubmed-meshheading:1168096-Furans,
pubmed-meshheading:1168096-Isomerism,
pubmed-meshheading:1168096-Leukemia L1210,
pubmed-meshheading:1168096-Time Factors
|
| pubmed:year |
1975
|
| pubmed:articleTitle |
In vitro biological evaluation of the R and S isomers of 1-(Tetrahydrofuran-2-yl)-5-fluorouracil.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|