| pubmed-article:11679632 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C1704826 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C0206364 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C0171484 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C1823153 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C2349976 | lld:lifeskim |
| pubmed-article:11679632 | lifeskim:mentions | umls-concept:C1552644 | lld:lifeskim |
| pubmed-article:11679632 | pubmed:issue | 5549 | lld:pubmed |
| pubmed-article:11679632 | pubmed:dateCreated | 2001-12-13 | lld:pubmed |
| pubmed-article:11679632 | pubmed:abstractText | ErbB-4 is a transmembrane receptor tyrosine kinase that regulates cell proliferation and differentiation. After binding of its ligand heregulin (HRG) or activation of protein kinase C (PKC) by 12-O-tetradecanoylphorbol-13-acetate (TPA), the ErbB-4 ectodomain is cleaved by a metalloprotease. We now report a subsequent cleavage by gamma-secretase that releases the ErbB-4 intracellular domain from the membrane and facilitates its translocation to the nucleus. gamma-Secretase cleavage was prevented by chemical inhibitors or a dominant negative presenilin. Inhibition of gamma-secretase also prevented growth inhibition by HRG. gamma-Secretase cleavage of ErbB-4 may represent another mechanism for receptor tyrosine kinase-mediated signaling. | lld:pubmed |
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| pubmed-article:11679632 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11679632 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11679632 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:11679632 | pubmed:issn | 0036-8075 | lld:pubmed |
| pubmed-article:11679632 | pubmed:author | pubmed-author:MurphyM PMP | lld:pubmed |
| pubmed-article:11679632 | pubmed:author | pubmed-author:CarpenterGG | lld:pubmed |
| pubmed-article:11679632 | pubmed:author | pubmed-author:GoldeT ETE | lld:pubmed |
| pubmed-article:11679632 | pubmed:author | pubmed-author:NiC YCY | lld:pubmed |
| pubmed-article:11679632 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11679632 | pubmed:day | 7 | lld:pubmed |
| pubmed-article:11679632 | pubmed:volume | 294 | lld:pubmed |
| pubmed-article:11679632 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11679632 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11679632 | pubmed:pagination | 2179-81 | lld:pubmed |
| pubmed-article:11679632 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:11679632 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11679632 | pubmed:articleTitle | gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. | lld:pubmed |
| pubmed-article:11679632 | pubmed:affiliation | Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. | lld:pubmed |
| pubmed-article:11679632 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11679632 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11679632 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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