| pubmed-article:11606733 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C0021311 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C0226896 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C0205531 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C0442027 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C1527415 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C0524914 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C1332700 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C1328819 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C0231491 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C0935763 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:11606733 | lifeskim:mentions | umls-concept:C1098714 | lld:lifeskim |
| pubmed-article:11606733 | pubmed:issue | 22 | lld:pubmed |
| pubmed-article:11606733 | pubmed:dateCreated | 2001-10-24 | lld:pubmed |
| pubmed-article:11606733 | pubmed:abstractText | We describe here the identification and properties of SCH-C (SCH 351125), a small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor. SCH-C, an oxime-piperidine compound, is a specific CCR5 antagonist as determined in multiple receptor binding and signal transduction assays. This compound specifically inhibits HIV-1 infection mediated by CCR5 in U-87 astroglioma cells but has no effect on infection of CXCR4-expressing cells. SCH-C has broad and potent antiviral activity in vitro against primary HIV-1 isolates that use CCR5 as their entry coreceptor, with mean 50% inhibitory concentrations ranging between 0.4 and 9 nM. Moreover, SCH-C strongly inhibits the replication of an R5-using HIV-1 isolate in SCID-hu Thy/Liv mice. SCH-C has a favorable pharmacokinetic profile in rodents and primates with an oral bioavailability of 50-60% and a serum half-life of 5-6 h. On the basis of its novel mechanism of action, potent antiviral activity, and in vivo pharmacokinetic profile, SCH-C is a promising new candidate for therapeutic intervention of HIV infection. | lld:pubmed |
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| pubmed-article:11606733 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11606733 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11606733 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11606733 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11606733 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:11606733 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:LiuJJ | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:ShapiroSS | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:EndresMM | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:DaviesLL | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:MorenoM EME | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:BaroudyB MBM | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:HolRR | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:McCombieSS | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:MooreJ PJP | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:FawziA BAB | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:DOR | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:ReyesG RGR | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:GAYJ GJG | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:CuqPP | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:ChouC CCC | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:StoddartC ACA | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:TrkolaAA | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:GreenleeW JWJ | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:CladerJ WJW | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:Palai?DD | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:WagnerN ENE | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:StrizkiJ MJM | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:Pugliese-Sivo... | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:WojcikLL | lld:pubmed |
| pubmed-article:11606733 | pubmed:author | pubmed-author:TagatJ RJR | lld:pubmed |
| pubmed-article:11606733 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11606733 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:11606733 | pubmed:volume | 98 | lld:pubmed |
| pubmed-article:11606733 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11606733 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11606733 | pubmed:pagination | 12718-23 | lld:pubmed |
| pubmed-article:11606733 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
