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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
20
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pubmed:dateCreated |
2001-10-18
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pubmed:abstractText |
We have performed association studies between a novel coding single nucleotide polymorphism (D104N) in endostatin, one of the most potent inhibitors of angiogenesis, and prostate cancer. We observed that heterozygous N104 individuals have a 2.5 times increased chance of developing prostate cancer as compared with homozygous D104 subjects (odds ratio, 2.4; 95% confidence interval, 1.4-4.16). Modeling of the endostatin mutant showed that the N104 protein is stable. These results together with the observation that residue 104 is evolutionary conserved lead us to propose that: (a) the DNA segment containing this residue might contain a novel interaction site to a yet unknown receptor; and (b) the presence of N104 impairs the function of endostatin.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:AlvesV AVA,
pubmed-author:CamargoAA,
pubmed-author:GodoiP HPH,
pubmed-author:IughettiPP,
pubmed-author:Moreira-FilhoC ACA,
pubmed-author:MoreiraE SES,
pubmed-author:OlivaGG,
pubmed-author:Passos-BuenoM RMR,
pubmed-author:SertiéA LAL,
pubmed-author:SimpsonAA,
pubmed-author:SoaresFF,
pubmed-author:SuzukiOO,
pubmed-author:ZorickTT,
pubmed-author:di LoretoCC
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7375-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:11606364-Adenocarcinoma,
pubmed-meshheading:11606364-Aged,
pubmed-meshheading:11606364-Angiogenesis Inhibitors,
pubmed-meshheading:11606364-Collagen,
pubmed-meshheading:11606364-Endostatins,
pubmed-meshheading:11606364-Genetic Predisposition to Disease,
pubmed-meshheading:11606364-Humans,
pubmed-meshheading:11606364-Male,
pubmed-meshheading:11606364-Middle Aged,
pubmed-meshheading:11606364-Models, Molecular,
pubmed-meshheading:11606364-Peptide Fragments,
pubmed-meshheading:11606364-Polymorphism, Genetic,
pubmed-meshheading:11606364-Prostatic Neoplasms,
pubmed-meshheading:11606364-Static Electricity,
pubmed-meshheading:11606364-Surface Properties
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pubmed:year |
2001
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pubmed:articleTitle |
A polymorphism in endostatin, an angiogenesis inhibitor, predisposes for the development of prostatic adenocarcinoma.
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pubmed:affiliation |
Centro de Estudos do Genoma Humano, Departamento de Biologia, Instituto de Biociências, USP, São Paulo 05508-900, Brasil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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