rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2001-10-9
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pubmed:abstractText |
Fourteen drug-naive and 11 levodopa-treated patients with idiopathic restless legs syndrome (RLS), and 10 controls age-matched to each RLS group separately were examined with polysomnography (PSG), [(123)I]-(N)-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane ((123)I-IPT) SPECT, and [(123)I]-(S)-2-hydroxy-3-iodo-6-methoxy-[(1-ethyl-2-pyrrolidinyl)methyl] benzamide ((123)I-IBZM) SPECT. Drug-naive and levodopa-treated patients with RLS and controls showed similar striatal dopamine transporter and dopamine D(2)-receptor binding, the latter declining with age. The authors conclude that striatal dopamine transporter and receptor density is normal in drug-naive and levodopa-treated patients with RLS.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
AIM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0028-3878
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
9
|
pubmed:volume |
57
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1307-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11591854-Aged,
pubmed-meshheading:11591854-Benzamides,
pubmed-meshheading:11591854-Dopamine Agents,
pubmed-meshheading:11591854-Dopamine Antagonists,
pubmed-meshheading:11591854-Female,
pubmed-meshheading:11591854-Humans,
pubmed-meshheading:11591854-Iodine Radioisotopes,
pubmed-meshheading:11591854-Levodopa,
pubmed-meshheading:11591854-Male,
pubmed-meshheading:11591854-Middle Aged,
pubmed-meshheading:11591854-Polysomnography,
pubmed-meshheading:11591854-Pyrrolidines,
pubmed-meshheading:11591854-Restless Legs Syndrome,
pubmed-meshheading:11591854-Tomography, Emission-Computed, Single-Photon,
pubmed-meshheading:11591854-Tropanes
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pubmed:year |
2001
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pubmed:articleTitle |
Normal IPT and IBZM SPECT in drug-naive and levodopa-treated idiopathic restless legs syndrome.
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pubmed:affiliation |
Department of Neurology, Ludwig-Maximilians University, Munich, Germany. eisen@nefo.med.uni-muenchen.de
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pubmed:publicationType |
Journal Article
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