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rdf:type |
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lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0021289,
umls-concept:C0021745,
umls-concept:C0023884,
umls-concept:C0026809,
umls-concept:C0152254,
umls-concept:C0332282,
umls-concept:C0333348,
umls-concept:C1292733,
umls-concept:C1302234,
umls-concept:C1446680
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pubmed:issue |
1
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pubmed:dateCreated |
2001-9-28
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pubmed:abstractText |
Mice lacking the suppressor of cytokine signalling-1 (SOCS1) die within weeks of birth with extensive fatty degeneration of the liver, consistent with acute hepatic toxicity to interferon-gamma (IFN-gamma), and inflammation of multiple organs. We show here that treatment for 1 week from birth with neutralizing antibody to IFN-gamma rescues SOCS1-/- mice from lethal liver disease but the mice subsequently succumb to chronic inflammatory lesions characterized by T-lymphocyte infiltration of skeletal muscle, pancreas, lung, liver and skin. Elevated blood levels of eosinophils, neutrophils and platelets were also observed and the thymic lymphocyte population was depleted of CD4+ CD8+ T cells and showed a reduced CD4 : CD8 ratio. All T-cell populations in thymus, spleen and lymph node exhibited an increased proportion of cells bearing the activation marker CD44. These data suggest an important role for SOCS1 in T-lymphocyte regulation.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
104
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
92-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11576226-Animals,
pubmed-meshheading:11576226-Animals, Newborn,
pubmed-meshheading:11576226-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11576226-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11576226-Carrier Proteins,
pubmed-meshheading:11576226-Chronic Disease,
pubmed-meshheading:11576226-Fatty Liver,
pubmed-meshheading:11576226-Hepatitis, Animal,
pubmed-meshheading:11576226-Inflammation,
pubmed-meshheading:11576226-Interferon-gamma,
pubmed-meshheading:11576226-Lymphocyte Count,
pubmed-meshheading:11576226-Mice,
pubmed-meshheading:11576226-Mice, Inbred C57BL,
pubmed-meshheading:11576226-Mice, Mutant Strains,
pubmed-meshheading:11576226-Repressor Proteins,
pubmed-meshheading:11576226-Suppressor of Cytokine Signaling Proteins,
pubmed-meshheading:11576226-beta-Galactosidase
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pubmed:year |
2001
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pubmed:articleTitle |
Neutralization of interferon-gamma in neonatal SOCS1-/- mice prevents fatty degeneration of the liver but not subsequent fatal inflammatory disease.
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pubmed:affiliation |
The Walter and Eliza Hall Institute of Medical Research and the Cooperative Research Centre for Cellular Growth Factors, Post Office, Royal Melbourne Hospital, Victoria, Australia. bullen@wehi.edu.au
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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