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rdf:type |
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lifeskim:mentions |
umls-concept:C0003320,
umls-concept:C0012854,
umls-concept:C0020971,
umls-concept:C0033684,
umls-concept:C0041221,
umls-concept:C0181586,
umls-concept:C0243043,
umls-concept:C1155229,
umls-concept:C1511636,
umls-concept:C1545588,
umls-concept:C1708111
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pubmed:issue |
10
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pubmed:dateCreated |
2001-9-12
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pubmed:abstractText |
Murine immunization with Trypanosoma cruzi KMP11-HSP70 fused genes but not the KMP11 gene alone elicited both an immunoglobulin G2a long-lasting humoral immune response against KMP11 protein and activation of CD8+ cytotoxic T lymphocytes specific for two KMP11 peptides containing A2 motifs. Moreover, protection against the parasite challenge was observed after immunization with the chimeric gene.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-10637285,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-10668791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-10886404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-11099308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-11248808,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-11298135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-1423218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-1491299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-1706750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-2104903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-2516504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-7638857,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-7890324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-7927770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-7937907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-8250874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-8258708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-8273735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-8370164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-8543845,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-8561458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-8705858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-8937280,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-9143702,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-9311915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-9334371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-9371814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-9570550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-9714418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-9780143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11553607-9784506
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Protozoan,
http://linkedlifedata.com/resource/pubmed/chemical/HSP70 Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protozoan Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, DNA,
http://linkedlifedata.com/resource/pubmed/chemical/kinetoplastid membrane protein 11...
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6558-63
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:11553607-Adjuvants, Immunologic,
pubmed-meshheading:11553607-Animals,
pubmed-meshheading:11553607-Antibodies, Protozoan,
pubmed-meshheading:11553607-Antibody Formation,
pubmed-meshheading:11553607-Artificial Gene Fusion,
pubmed-meshheading:11553607-COS Cells,
pubmed-meshheading:11553607-Cercopithecus aethiops,
pubmed-meshheading:11553607-Chagas Disease,
pubmed-meshheading:11553607-DNA, Protozoan,
pubmed-meshheading:11553607-Disease Models, Animal,
pubmed-meshheading:11553607-Female,
pubmed-meshheading:11553607-Gene Expression,
pubmed-meshheading:11553607-HSP70 Heat-Shock Proteins,
pubmed-meshheading:11553607-Immunoglobulin G,
pubmed-meshheading:11553607-Membrane Glycoproteins,
pubmed-meshheading:11553607-Mice,
pubmed-meshheading:11553607-Mice, Inbred BALB C,
pubmed-meshheading:11553607-Mice, Inbred C57BL,
pubmed-meshheading:11553607-Protozoan Proteins,
pubmed-meshheading:11553607-Protozoan Vaccines,
pubmed-meshheading:11553607-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:11553607-Trypanosoma cruzi,
pubmed-meshheading:11553607-Vaccination,
pubmed-meshheading:11553607-Vaccines, DNA
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pubmed:year |
2001
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pubmed:articleTitle |
DNA immunization with Trypanosoma cruzi HSP70 fused to the KMP11 protein elicits a cytotoxic and humoral immune response against the antigen and leads to protection.
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pubmed:affiliation |
Departamento de Biología Molecular, Instituto de Parasitología y Biomedicina López Neyra, CSIC, 18001 Granada, Spain.
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pubmed:publicationType |
Journal Article
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