| pubmed-article:11545735 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11545735 | lifeskim:mentions | umls-concept:C0663446 | lld:lifeskim |
| pubmed-article:11545735 | lifeskim:mentions | umls-concept:C0035679 | lld:lifeskim |
| pubmed-article:11545735 | lifeskim:mentions | umls-concept:C0079904 | lld:lifeskim |
| pubmed-article:11545735 | lifeskim:mentions | umls-concept:C1519591 | lld:lifeskim |
| pubmed-article:11545735 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:11545735 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11545735 | pubmed:dateCreated | 2001-9-7 | lld:pubmed |
| pubmed-article:11545735 | pubmed:abstractText | To stimulate transcriptional elongation of HIV-1 genes, the transactivator Tat recruits the positive transcription elongation factor b (P-TEFb) to the initiating RNA polymerase II (RNAPII). We found that the activation of transcription by RelA also depends on P-TEFb. Similar to Tat, RelA activated transcription when tethered to RNA. Moreover, TNF-alpha triggered the recruitment of P-TEFb to the NF-kappaB-regulated IL-8 gene. While the formation of the transcription preinitiation complex (PIC) remained unaffected, DRB, an inhibitor of P-TEFb, prevented RNAPII from elongating on the IL-8 gene. Remarkably, DRB inhibition sensitized cells to TNF-alpha-induced apoptosis. Thus, NF-kappaB requires P-TEFb to stimulate the elongation of transcription and P-TEFb plays an unexpected role in regulating apoptosis. | lld:pubmed |
| pubmed-article:11545735 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11545735 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11545735 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11545735 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11545735 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:11545735 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:11545735 | pubmed:author | pubmed-author:KanazawaSS | lld:pubmed |
| pubmed-article:11545735 | pubmed:author | pubmed-author:PeterlinB MBM | lld:pubmed |
| pubmed-article:11545735 | pubmed:author | pubmed-author:Jabrane-Ferra... | lld:pubmed |
| pubmed-article:11545735 | pubmed:author | pubmed-author:NissenR MRM | lld:pubmed |
| pubmed-article:11545735 | pubmed:author | pubmed-author:BarboricMM | lld:pubmed |
| pubmed-article:11545735 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11545735 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:11545735 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11545735 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11545735 | pubmed:pagination | 327-37 | lld:pubmed |
| pubmed-article:11545735 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11545735 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11545735 | pubmed:articleTitle | NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II. | lld:pubmed |
| pubmed-article:11545735 | pubmed:affiliation | Howard Hughes Medical Institute Departments of Medicine, Microbiology, and Immunology University of California at San Francisco 94143, USA. | lld:pubmed |
| pubmed-article:11545735 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11545735 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11545735 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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