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pubmed-article:11535886pubmed:abstractTextRecombinant activated factor VII (rFVIIa) was approved for treatment of hemorrhages in patients with hemophilia who develop inhibitors to factors VIII or IX. Conditions with increased thromboembolic risk, including trauma with or without disseminated intravascular coagulation, were considered a contraindication for the drug. The mechanism of action of rFVIIa suggests enhancement of hemostasis limited to the site of injury without systemic activation of the coagulation cascade. Therefore, use of the drug in trauma patients suffering uncontrolled hemorrhage appears to be rational.lld:pubmed
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pubmed-article:11535886pubmed:articleTitleRecombinant activated factor VII for adjunctive hemorrhage control in trauma.lld:pubmed
pubmed-article:11535886pubmed:affiliationNational Hemophilia Center, Chaim Sheba Medical Center, Tel Hashomer 52621, Israel. hemophil@trendline.co.illld:pubmed
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