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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2001-8-30
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pubmed:abstractText |
A series of glycolic and mandelic acid derivatives was synthesized and investigated for their factor Xa inhibitory activity. These analogues are highly potent and selective inhibitors against fXa. In a rabbit deep vein thrombosis model, compound 26 showed significant antithrombotic effects (81% inhibition of thrombus formation) at 1.1 microM plasma concentration following intravenous administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:DoughanBB,
pubmed-author:HollenbachSS,
pubmed-author:HuangBB,
pubmed-author:Kane-MaguireKK,
pubmed-author:KanterJ PJP,
pubmed-author:MalinowskiJJ,
pubmed-author:MarloweC KCK,
pubmed-author:ParkGG,
pubmed-author:ScarboroughR MRM,
pubmed-author:SinhaUU,
pubmed-author:SuTT,
pubmed-author:WongPP,
pubmed-author:WoolfreyJJ,
pubmed-author:WuYY,
pubmed-author:ZhuB YBY
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2279-82
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11527714-Acetanilides,
pubmed-meshheading:11527714-Amidines,
pubmed-meshheading:11527714-Animals,
pubmed-meshheading:11527714-Biological Availability,
pubmed-meshheading:11527714-Blood Coagulation Tests,
pubmed-meshheading:11527714-Drug Design,
pubmed-meshheading:11527714-Drug Evaluation, Preclinical,
pubmed-meshheading:11527714-Factor Xa,
pubmed-meshheading:11527714-Fibrinolysin,
pubmed-meshheading:11527714-Inhibitory Concentration 50,
pubmed-meshheading:11527714-Injections, Intravenous,
pubmed-meshheading:11527714-Mandelic Acids,
pubmed-meshheading:11527714-Phenylacetates,
pubmed-meshheading:11527714-Rabbits,
pubmed-meshheading:11527714-Rats,
pubmed-meshheading:11527714-Rats, Sprague-Dawley,
pubmed-meshheading:11527714-Serine Proteinase Inhibitors,
pubmed-meshheading:11527714-Structure-Activity Relationship,
pubmed-meshheading:11527714-Venous Thrombosis
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pubmed:year |
2001
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pubmed:articleTitle |
Design and synthesis of glycolic and mandelic acid derivatives as factor Xa inhibitors.
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pubmed:affiliation |
COR Therapeutics, Inc., 256 East Grand Avenue, South San Francisco, CA 94080, USA. tsu@corr.com
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pubmed:publicationType |
Journal Article
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