Source:http://linkedlifedata.com/resource/pubmed/id/11517431
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
2001-8-22
|
| pubmed:abstractText |
Cytomegalovirus (CMV)-immune recovery was characterized in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy. CMV lymphocyte proliferation (LP), responder-cell frequency (RCF), and interferon (IFN)-gamma and interleukin (IL)-2 secretion were studied in CMV-seropositive HIV-infected patients and in CMV-seropositive HIV-uninfected control subjects. HIV-infected patients and control subjects had similar proportions of IL-2 and IFN-gamma, but levels were lower in HIV-infected patients. LP and RCF were significantly less frequent and of lower magnitude in HIV-infected patients. The measures of CMV cell-mediated immunity were correlated in HIV-uninfected but not in HIV-infected subjects. To investigate this, IL-2, IL-12, anti-CD28 plus anti-CD49d, or anti-IL-10 was added in vitro, with no effect on LP. However, CD8 cell depletion of mononuclear cells from HIV-infected patients increased LP responses to levels similar to those of uninfected control subjects; before depletion, only RCF correlated with CD4 cell counts, but after depletion, LP also correlated with CD4 cell counts.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
184
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
707-12
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| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:11517431-AIDS-Related Opportunistic Infections,
pubmed-meshheading:11517431-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:11517431-CD4-Positive T-Lymphocytes,
pubmed-meshheading:11517431-CD8-Positive T-Lymphocytes,
pubmed-meshheading:11517431-Cells, Cultured,
pubmed-meshheading:11517431-Cytomegalovirus,
pubmed-meshheading:11517431-Cytomegalovirus Infections,
pubmed-meshheading:11517431-HIV Infections,
pubmed-meshheading:11517431-HIV Seronegativity,
pubmed-meshheading:11517431-Humans,
pubmed-meshheading:11517431-Immunity, Cellular,
pubmed-meshheading:11517431-Immunologic Memory,
pubmed-meshheading:11517431-Interferon-gamma,
pubmed-meshheading:11517431-Interleukin-2,
pubmed-meshheading:11517431-Lymphocyte Activation,
pubmed-meshheading:11517431-Reference Values,
pubmed-meshheading:11517431-Regression Analysis,
pubmed-meshheading:11517431-T-Lymphocytes
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Inconsistent reconstitution of cytomegalovirus-specific cell-mediated immunity in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy.
|
| pubmed:affiliation |
Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA. adriana.weinberg@uchsc.edu
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|